2-Amino-3-hydroxypyridine

Base Information

• Chemical Name: 2-Amino-3-hydroxypyridine
• CAS No.: 16867-03-1
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933.39
• European Community (EC) Number: 240-886-8
• NSC Number: 136806
• UNII: P8740PEW4B
• DSSTox Substance ID: DTXSID50168588
• Nikkaji Number: J207.966F
• Wikidata: Q27286357
• ChEMBL ID: CHEMBL4777856
• Mol file: 16867-03-1.mol

Synonyms:2-amino-3-hydroxypyridine;3-hydroxy-2-aminopyridine

Chemical Property of 2-Amino-3-hydroxypyridine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 1.75E-06mmHg at 25°C
• Melting Point: 168-172 °C(lit.)
• Refractive Index: 1.4800 (estimate)
• Boiling Point: 385.187 °C at 760 mmHg
• PKA: 5.15±0.10(Predicted)
• Flash Point: 186.755 °C
• PSA: 59.14000
• Density: 1.32 g/cm³
• LogP: 0.95060
• Storage Temp.: Room temperature.
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 110.048012819
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T,Xn
• Hazard Codes: Xi,T,Xn
• Statements: 36/37/38-25-40
• Safety Statements: 26-45-37/39-28A-36-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)N)O
• Uses: 2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.

Technology Process of 2-Amino-3-hydroxypyridine

There total 19 articles about 2-Amino-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-hydroxy-3-nitropyridine (6332-56-5) → 2-amino-3-hydroxypyridine (16867-03-1)

Guidance literature:

palladium-carbon; In methanol;

Reference yield: 79.0%

2-amino-3-hydroxypyridinesulfonic acid salt → 2-amino-3-hydroxypyridine (16867-03-1)

Guidance literature:

In water; at 35 - 90 ℃; for 1.5h; Time;

Reference yield: 77.1%

2-imino-3-hydroxypyridinesulfonic acid (16867-02-0) → 2-amino-3-hydroxypyridine (16867-03-1)

Guidance literature:

In water; at 95 ℃; for 1h; Temperature; Large scale;

upstream raw materials:

2-iodo-3-hydroxypyridine

3-hydroxypyridine-2-carboxamide

2-Amino-3-(ethoxy)pyridine

3-hydroxy-2-nitropyridine

Downstream raw materials:

2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

2-oxo-oxazolo[4,5-b]pyridine-3-carboxylic acid ethyl ester

7,9-Dinitro-1-azaphenoxazin

2-(N-benzoylbenzamido)pyridine-3-yl benzoate