(1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid

Base Information

Chemical Name:(1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid
CAS No.:21448-77-1
Molecular Formula:C8H12 O2
Molecular Weight:140.182
Hs Code.:
European Community (EC) Number:850-463-5
Mol file:21448-77-1.mol

Synonyms:21448-77-1;(1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid;(1S,6R)-bicyclo[4.1.0]heptane-7-carboxylic acid;exo-Bicyclo[4.1.0]heptane-7-carboxylic acid;(1R,6S,7R)-bicyclo[4.1.0]heptane-7-carboxylic acid;starbld0010403;SCHEMBL3984121;AKOS006375550;AKOS006378606;AKOS006378977;Cis-Bicyclo[4.1.0]heptane-7-carboxylic acid;EN300-6987313

Suppliers and Price of (1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid

Chemical Property:

Vapor Pressure:0.00807mmHg at 25°C
Boiling Point:247.8°Cat760mmHg
Flash Point:113.8°C
Density:1.193g/cm³
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:140.083729621
Heavy Atom Count:10
Complexity:153

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2C(C1)C2C(=O)O
Isomeric SMILES:C1CC[C@H]2[C@@H](C1)C2C(=O)O

Technology Process of (1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid

There total 21 articles about (1R,6S)-bicyclo[4.1.0]heptane-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4729-31-1,52917-64-3,4729-30-0
ethyl exo-7-bicyclo<4.1.0>heptanecarboxylate

: 21448-77-1
(1α,6α,7α)-bicyclo[4.1.0]heptane-7-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm401420j

Reference yield: 75.0%

: 52917-64-3
ethyl 7-norcaranecarboxylate

: 21448-77-1
(1α,6α,7α)-bicyclo[4.1.0]heptane-7-carboxylic acid

Guidance literature:: With sodium hydroxide;
DOI:10.1039/P29800001473

Reference yield:

: 110-83-8
cyclohexene

: 21448-77-1
(1α,6α,7α)-bicyclo[4.1.0]heptane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: CuI / Heating

2: (i) CF₃CO₃H, Na₂HPO₄, (ii) aq. KOH

With copper(l) iodide;
DOI:10.1021/jo00821a034