4-Hydroxy-3-methoxyamphetamine Hydrochloride

Base Information

• Chemical Name: 4-Hydroxy-3-methoxyamphetamine Hydrochloride
• CAS No.: 13062-61-8
• Molecular Formula: C10H15 N O2 . Cl H
• Molecular Weight: 217.696
• Hs Code.: 2922509090
• European Community (EC) Number: 889-832-0
• ChEMBL ID: CHEMBL1996669
• DSSTox Substance ID: DTXSID60504332
• NSC Number: 172191
• Mol file: 13062-61-8.mol

Synonyms:13062-61-8;d,l-HMA.HCl;4-(2-aminopropyl)-2-methoxyphenol;hydrochloride;4-Hydroxy-3-methoxyamphetamine Hydrochloride;Phenol, 4-(2-aminopropyl)-2-methoxy-, hydrochloride (1:1);4-Hydroxy-3-methoxy Amphetamine Hydrochloride;4-(2-Aminopropyl)-2-methoxyphenol Hydrochloride;CHEMBL1996669;DTXSID60504332;d,l-HMA.HCl, 1mg/ml in Methanol;NSC172191;NSC-172191;PD019141;4-hydroxy-3-Methoxyamphetamine (hydrochloride);EN300-8690818;Z4119887033;4-(2-Aminopropyl)-2-methoxyphenol--hydrogen chloride (1/1);Alpha-methyl-beta-(3-methoxy-4-hydroxyphenyl)ethylamine hydrochloride

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Chemical Property of 4-Hydroxy-3-methoxyamphetamine Hydrochloride

Chemical Property:

• Boiling Point: 310.8°Cat760mmHg
• Flash Point: 141.8°C
• PSA: 55.48000
• Density: 1.096g/cm³
• LogP: 2.79280
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 217.0869564
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)O)OC)N.Cl
• Uses: 4-Hydroxy-3-methoxy Amphetamine is a metabolite of 3,4-methylenedioxymethamphetamine (MDMA). 4-Hydroxy-3-methoxy Amphetamine was significantly less potent than MDMA at inhibiting [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines. Labelled analogue of 4-Hydroxy-3-methoxy Amphetamine, a metabolite of 3,4-methylenedioxymethamphetamine (MDMA). 4-Hydroxy-3-methoxy Amphetamine was significantly less potent than MDMA at inhibiting [ 3H]noradrenaline and [3H]5-HT transport in mammalian cell lines.

Technology Process of 4-Hydroxy-3-methoxyamphetamine Hydrochloride

There total 2 articles about 4-Hydroxy-3-methoxyamphetamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-1-(4-benzyloxy-3-methoxyphenyl)propane hydrochloride (89356-56-9) → 4-hydroxy-3-methoxyamphetamine hydrochloride (13062-61-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 90 ℃; for 4h; under 2585.7 Torr;

DOI:10.1021/jm00183a006

Reference yield: 36.0%

1-(4-hydroxy-3-methoxyphenyl)2-propanone (2503-46-0) → 4-hydroxy-3-methoxyamphetamine hydrochloride (13062-61-8)

Guidance literature:

1-(4-hydroxy-3-methoxyphenyl)2-propanone; In methanol; at 20 ℃; for 3.5h;

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 48h; pH=4 - 6; Further stages.;

DOI:10.1038/sj.bjp.0707473

upstream raw materials:

2-amino-1-(4-benzyloxy-3-methoxyphenyl)propane hydrochloride

1-(4-hydroxy-3-methoxyphenyl)2-propanone