2-AMINO-1-THIOPHEN-2-YL-ETHANOL

Base Information

• Chemical Name: 2-AMINO-1-THIOPHEN-2-YL-ETHANOL
• CAS No.: 10021-67-7
• Molecular Formula: C₆H₉NOS
• Molecular Weight: 143.21
• Mol file: 10021-67-7.mol

Synonyms:2-Thiophenemethanol,a-(aminomethyl)-, (S)-;2-Thiophenemethanol, a-(aminomethyl)-, (S)-(-)- (8CI)

Chemical Property of 2-AMINO-1-THIOPHEN-2-YL-ETHANOL

Chemical Property:

• Vapor Pressure: 0.000557mmHg at 25°C
• Melting Point: 82-83°C
• Boiling Point: 298.7°C at 760 mmHg
• Flash Point: 134.5°C
• Density: 1.259g/cm³

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-(thiophen-2-yl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-1-THIOPHEN-2-YL-ETHANOL

There total 9 articles about 2-AMINO-1-THIOPHEN-2-YL-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-(+)-2-azido-1-(2'-thienyl)ethanol (473552-25-9) → (R)-(+)-2-amino-1-(2'-thienyl)ethanol (10021-67-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 15h;

DOI:10.1016/S0957-4166(02)00322-1

Reference yield: 85.0%

2-amminometil-2-tienilchetone (313276-47-0) → α-(aminomethyl)-2-thiophenmethanol (62019-66-3,10021-67-7)

Guidance literature:

With sodium tetrahydroborate; In water; for 2h; Ambient temperature;

Reference yield: 68.0%

<2S-(2α(S*),3aα,4β,7β,7aα)>-β-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)-oxy>-2-thiophenethanamin → <2S-(2α,3aα,4β,7β,7aα)>-2-Methoxy- (113775-57-8) + (R)-(+)-2-amino-1-(2'-thienyl)ethanol (10021-67-7)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1007/BF00813211

upstream raw materials:

N-[(thien-2-ylcarbonyl)methyl]amine hydrochloride

2-amminometil-2-tienilchetone

water

2-(thiophen-2-yl)-2-((trimethylsilyl)oxy)acetonitrile

Downstream raw materials:

6-(2-tienil)-4-benzilmorfolin-3-one

2-(benzylamino)-1-(thien-2-yl)ethanol

Refernces

• 1、 Tae Cho, Byung,Kyu Kang, Sang,Hye Shin, Sung. "Application of optically active 1,2-diol monotosylates for synthesis of β-azido and β-amino alcohols with very high enantiomeric purity. Synthesis of enantiopure (R)-octopamine, (R)-tembamide and (R)-aegeline". . p. 1209 - 1217. Retrieved 2007/10/03.
• 2、 Noe, C. R.,Knollmueller, M.,Gaertner, P.,Fleischhacker, W.,Katikarides, E.. "Aminoalcohols II: Preparation of Enantiomerically Pure Pharmacologically Active β-Aminoalcohols". . p. 481 - 494. Retrieved 2007/10/02.