113775-57-8

Upstream product

• 67-56-1 methanol 
• 1237738-33-8 C₃₄H₄₀O₄ 
• 113775-62-5 <2R-(2α(S^*),3aα,4β,7β,7aα)>-2-(2,2-Dimethyl-1-phenylpropoxy)-octahydro-7,8,8-trimethyl-4,7-methanobenzofuran 
• 177018-40-5 {[(R)-2-(2,5-Dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 177018-39-2 {[(S)-2-(2,5-Dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 120686-94-4 <2R-(2α(2R*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3S*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol 
• 120786-24-5 <2R-(2α(2R*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3R*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol 
• 120686-94-4 <2R-(2α(2S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3Ξ*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol 

Downstream Products

• 108031-80-7 (2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] 

Relevant academic research and scientific papers

Application of meso-hydrobenzoin-derived chiral auxiliaries for the stereoselective synthesis of highly substituted pyrrolidines by 1,3-dipolar cycloaddition of azomethine ylides

The metal-catalyzed stereoselective 1,3-dipolar cycloaddition of azomethine ylides and acrylates using recyclable meso-hydrobenzoin-derived chiral auxiliaries is described. Cleavage of the auxiliary leads to highly substituted pyrrolidines in up to 87% en

Enantiomerically pure poly(oxymethylene) helices: Correlating helicity with centrochirality

A first series of enantiomerically pure helical oligo(formaldehyde)s (=oligo(oxymethylen)s) 16-20 was synthesized. To induce the chiral uniformity of the helices, we used (1S)-2,2-dimethyl-1-phenylpropan-1-ol (14) to generate the end groups at the α and ω

A Separation Procedure for the Preparation of Enantiomerically Pure Midodrine

Racemic midodrine chlorohydrate (rac-1) was N-protected to yield the racemic products rac-2a-c. These were converted into the diastereomeric O-acetals 3a-c/4a-c, which can easily be separated by chromatography. After removal of the N- and O-protective gro

Aminoalcohols II: Preparation of Enantiomerically Pure Pharmacologically Active β-Aminoalcohols

A synthesis of β-aminoalcohols is described starting from racemic or enantiomerically pure α-hydroxynitriles which were O-protected using enantiomerically pure acetal type protective groups.Reduction with lithium aluminium hydride yielded O-protected β-aminoalcohols.Whenever diastereomeric O-protected cyanohydrins could not be separated, the mixture was reduced and the resulting O-protected aminoalcohols were separated.Removal of the protective group using hydrogen chloride and methanol yielded enantiomerically pure β-aminoalcohols or their corresponding hydrochlorides. - Keywords: 1,2-Amino-alcohols, enantiomerically pure; Lithium aluminium hydride reduction

Chiral Lactols, VIII - A Way for the Asymmetric Induction in the Formation of Sugars

The substituted glycol aldehyde 4 which bears an enantiomerically pure acetal-type protective group exhibiting the configuration of an α-L-sugar at the acetal centre is subjected to aldolization under basic conditions.The resulting products are reduced and characterized by comparison with reference compounds of known absolute configuration.L-Sugars are formed preferentially with L-erythrose being the main product.