3-(2-Thienyl)propanoic acid

Base Information

Chemical Name:3-(2-Thienyl)propanoic acid
CAS No.:5928-51-8
Molecular Formula:C7H8 O2 S
Molecular Weight:156.205
Hs Code.:29309099
European Community (EC) Number:626-697-7
DSSTox Substance ID:DTXSID30351552
Nikkaji Number:J569.061G
Wikidata:Q72508593
Mol file:5928-51-8.mol

Synonyms:5928-51-8;3-(2-Thienyl)propionic acid;3-(2-THIENYL)PROPANOIC ACID;2-thiophenepropanoic acid;2-Thiophenepropionic acid;3-thiophen-2-ylpropanoic acid;3-(thiophen-2-yl)propanoic acid;MFCD00047093;3-Thiophen-2-yl-propionic acid;Maybridge3_005592;thiolpropionic acid;3-(2-Thienyl)propionicacid;SCHEMBL654985;3-thiophen-2-ylpropionic acid;3-(2-thienyl) propanoic acid;2-Thiophenepropionic acid, 98%;3-thiophene-2-yl-propionic acid;DTXSID30351552;MJPVYTKZYZPIQA-UHFFFAOYSA-N;HMS1446O04;AMY37950;CCG-54221;GEO-02874;AKOS000313648;AC-6474;IDI1_016979;CS-11098;SY005413;CS-0043395;FT-0613596;EN300-11573;J-640123;J-800127;SR-01000643332-1;Z57052863

Suppliers and Price of 3-(2-Thienyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(Thiophen-2-yl)propionicAcid
100mg
$ 50.00

Sigma-Aldrich
Eprosartan Related Compound B United States Pharmacopeia (USP) Reference Standard
15mg
$ 1120.00

Sigma-Aldrich
2-Thiophenepropionic acid 98%
5g
$ 109.00

Sigma-Aldrich
2-Thiophenepropionic acid 98%
1g
$ 36.90

Heterocyclics
2-Thiophenepropionic acid 97%
5g
$ 66.00

Heterocyclics
2-Thiophenepropionic acid 97%
100g
$ 704.00

AstaTech
3-(2-THIENYL)PROPIONICACID 97%
4*25 / G
$ 744.00

AstaTech
3-(2-THIENYL)PROPIONICACID 97%
25 / G
$ 298.00

AstaTech
3-(2-THIENYL)PROPIONICACID 97%
5 / G
$ 139.00

Arctom
3-(2-Thienyl)propionicAcid 97%
1g
$ 42.00

Total 47 raw suppliers

Chemical Property of 3-(2-Thienyl)propanoic acid

Chemical Property:

Appearance/Colour:White solid.
Vapor Pressure:0mmHg at 25°C
Melting Point:46-49 °C(lit.)
Refractive Index:1.728
Boiling Point:280.5 °C at 760 mmHg
PKA:4.47±0.10(Predicted)
Flash Point:110 ºC
PSA：65.54000
Density:1.271 g/cm³
LogP:1.76530
Storage Temp.:2-8°C
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:156.02450067
Heavy Atom Count:10
Complexity:125

Purity/Quality:

97% ^*data from raw suppliers

3-(Thiophen-2-yl)propionicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CSC(=C1)CCC(=O)O
Uses 3-(2-THIENYL)PROPIONIC ACID is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive ag ent. 3-(Thiophen-2-yl)propionic Acid (Eprosartan USP Related Compound B) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.

Technology Process of 3-(2-Thienyl)propanoic acid

There total 1 articles about 3-(2-Thienyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19498-72-7
3-thiophen-2-yl-propan-1-ol

: 527-72-0
2-thiophenylcarboxylic acid

: 5928-51-8
3-(2-thienyl)propanoic acid

Guidance literature:: With oxygen; sodium t-butanolate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 24h; under 750.075 Torr; Solvent; Overall yield = 61 %; chemoselective reaction;
DOI:10.1002/cssc.201501359

Reference yield: 85.0%

: 5928-51-8
3-(2-thienyl)propanoic acid

: 127285-09-0
1-[1-(2-phenylethyl)-4-piperidinyl]methanamine

: N-[1-(2-PHENYLETHYL)-4-HYDROXY-4-PIPERIDINYL] METHYL-2-THIOPHENEPROPENAMIDE

Guidance literature:: With thionyl chloride; In tetrahydrofuran;

Reference yield: 85.0%

: 5928-51-8
3-(2-thienyl)propanoic acid

: 13633-25-5
1-Bromo-4-phenylbutane

: C₁₇H₂₀OS

Guidance literature:: With 6,6'-dimethyl-2,2'-bipyridine; nickel(II) bromide trihydrate; di-tert-butyl dicarbonate; sodium iodide; magnesium chloride; zinc; In N,N-dimethyl acetamide; at 30 ℃; for 24h; regioselective reaction;
DOI:10.1021/acscatal.9b00521