Rebimastat

Base Information

Chemical Name:Rebimastat
CAS No.:259188-38-0
Molecular Formula:C₂₃H₄₁N₅O₅S
Molecular Weight:499.675
Hs Code.:
UNII:1B47R6ZX4K
Nikkaji Number:J2.199.981D
Wikidata:Q27252183
NCI Thesaurus Code:C1875
Pharos Ligand ID:FB8N5U1W8HPS
Metabolomics Workbench ID:149835
ChEMBL ID:CHEMBL76222
Mol file:259188-38-0.mol

Synonyms:BMS-275291;D-2163;N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide

Suppliers and Price of Rebimastat

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BMS-275291 95.00%
5G
$ 4100.25

American Custom Chemicals Corporation
BMS-275291 95.00%
1G
$ 1726.73

Total 7 raw suppliers

Chemical Property of Rebimastat

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:8.35±0.10(Predicted)
Flash Point:°C
PSA：166.72000
Density:1.133g/cm³
LogP:2.20380
XLogP3:2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:499.28284060
Heavy Atom Count:34
Complexity:808

Purity/Quality:

95% ^*data from raw suppliers

BMS-275291 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(C(=O)NC)C(C)(C)C)NC(=O)C(CCN1C(=O)C(N(C1=O)C)(C)C)S
Isomeric SMILES:CC(C)C[C@@H](C(=O)N[C@H](C(=O)NC)C(C)(C)C)NC(=O)[C@H](CCN1C(=O)C(N(C1=O)C)(C)C)S
Recent ClinicalTrials:Paclitaxel + Carboplatin With/ut BMS-275291 in Advanced or Metastatic Non-small Cell Lung Cancer

Technology Process of Rebimastat

There total 7 articles about Rebimastat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860803-16-3
N-[2-chloro-4-(1,5,5-trimethylhydantyl)butanoyl]-L-leucyl-L-tert-leucine N-methylamide

: 259188-38-0
Rebimastat

Guidance literature:: With Amberlite hydrogen sulfide resin; In tetrahydrofuran; methanol; for 10h;
DOI:10.1021/ol050980y

Reference yield:

: 178933-95-4
L-leucyl-L-tert-leucine methyl amide

: 259188-38-0
Rebimastat

Guidance literature:: Multi-step reaction with 2 steps

1: 0.055 g / Celite 545 / tetrahydrofuran; methanol / 5 h

2: 0.055 g / Amberlite hydrogen sulfide resin / tetrahydrofuran; methanol / 10 h

With Amberlite hydrogen sulfide resin; Celite; In tetrahydrofuran; methanol;
DOI:10.1021/ol050980y

Reference yield:

: 860803-14-1
(R)-2-chloro-4-(1,5,5-trimethylhydantyl)butanoic acid pentachlorophenyl ester

: 259188-38-0
Rebimastat

Guidance literature:: Multi-step reaction with 2 steps

1: 0.055 g / Celite 545 / tetrahydrofuran; methanol / 5 h

2: 0.055 g / Amberlite hydrogen sulfide resin / tetrahydrofuran; methanol / 10 h

With Amberlite hydrogen sulfide resin; Celite; In tetrahydrofuran; methanol;
DOI:10.1021/ol050980y