N-(4-chloro-2-methyl-6-quinolyl)acetamide

Base Information

• Chemical Name: N-(4-chloro-2-methyl-6-quinolyl)acetamide
• CAS No.: 59611-57-3
• Molecular Formula: C12H11ClN2O
• Molecular Weight: 234.6815
• NSC Number: 19461
• DSSTox Substance ID: DTXSID20280968
• Wikidata: Q82014676
• Mol file: 59611-57-3.mol

Synonyms:59611-57-3;N-(4-chloro-2-methyl-6-quinolyl)acetamide;NSC19461;Oprea1_053151;SCHEMBL5989580;DTXSID20280968;CGKDHJPGFCSXQP-UHFFFAOYSA-N;NSC-19461;6-Acetamido-4-chloro-2-methylquinoline

Chemical Property of N-(4-chloro-2-methyl-6-quinolyl)acetamide

Chemical Property:

• Vapor Pressure: 5.17E-08mmHg at 25°C
• Boiling Point: 442.1°Cat760mmHg
• Flash Point: 221.2°C
• Density: 1.317g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 234.0559907
• Heavy Atom Count: 16
• Complexity: 272

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C)Cl

Technology Process of N-(4-chloro-2-methyl-6-quinolyl)acetamide

There total 9 articles about N-(4-chloro-2-methyl-6-quinolyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4-hydroxy-2-methylquinolin-6-yl)acetamide (1140-81-4) → 6-acetamide-4-chloro-2-methylquinoline (59611-57-3)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 0.5h;

DOI:10.1021/jm0002073

Reference yield:

N-acetyl-p-phenylenediamine (122-80-5) → 6-acetamide-4-chloro-2-methylquinoline (59611-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / methanol / 17 h / Heating

2: 88 percent / various solvent(s) / 0.17 h / 280 °C

3: 100 percent / POCl₃ / 0.5 h / 100 °C

With trichlorophosphate; In methanol;

DOI:10.1021/jm0002073

Reference yield:

methyl 3-(4-acetylaminophenylamino)crotonate → 6-acetamide-4-chloro-2-methylquinoline (59611-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / various solvent(s) / 0.17 h / 280 °C

2: 100 percent / POCl₃ / 0.5 h / 100 °C

With trichlorophosphate; In various solvent(s);

DOI:10.1021/jm0002073

upstream raw materials:

N-(4-hydroxy-2-methylquinolin-6-yl)acetamide

N-acetyl-p-phenylenediamine

6-amino-2-methylquinolin-4-ol

1-(4-chloro-2-methyl-[6]quinolyl)-ethanone

Downstream raw materials:

N-(4-methoxy-2-methyl-6-quinolyl)acetamide

N,N'-bis-(6-amino-2-methyl-[4]quinolyl)-hexanediyldiamine