2-[methyl(2-methylbenzyl)amino]ethanol

Base Information

• Chemical Name: 2-[methyl(2-methylbenzyl)amino]ethanol
• CAS No.: 94520-78-2
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.2588
• Mol file: 94520-78-2.mol

Synonyms:Ethanol,2-[methyl(o-methylbenzyl)amino]- (7CI);2-(N-2-Tolylmethyl-N-methylamino)ethanol; NSC 56216

Chemical Property of 2-[methyl(2-methylbenzyl)amino]ethanol

Chemical Property:

• Vapor Pressure: 0.00198mmHg at 25°C
• Boiling Point: 278.9°Cat760mmHg
• Flash Point: 97.4°C
• Density: 1.016g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[methyl(2-methylbenzyl)amino]ethanol

There total 7 articles about 2-[methyl(2-methylbenzyl)amino]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2-methylbenzyl bromide (89-92-9) → N-(2-hydroxyethyl)-N-(2-methylbenzyl)methylamine (94520-78-2)

Guidance literature:

In methanol; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2009.10.025

Reference yield:

3-Methyl-2-o-tolyl-oxazolidine (67625-13-2) → N-(2-hydroxyethyl)-N-(2-methylbenzyl)methylamine (94520-78-2)

Guidance literature:

With hydrogen; [1,4-bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; at 20 ℃; for 0.5h; under 37503 - 39003.1 Torr;

DOI:10.1055/s-2002-20039

Reference yield:

2-methylphenyl aldehyde (529-20-4) → N-(2-hydroxyethyl)-N-(2-methylbenzyl)methylamine (94520-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH*H₂O / benzene / Heating

2: H₂ / {Rh[1,4-bis(diphenylphosphino)butane]COD}BF₄ / methanol / 0.5 h / 20 °C / 37503 - 39003.1 Torr

With hydrogen; toluene-4-sulfonic acid; [1,4-bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; benzene;

DOI:10.1055/s-2002-20039

upstream raw materials:

N-benzyl-2-hydroxy-N,N-dimethylethanammonium bromide

(2-hydroxyethyl)(methyl)amine

2-methylbenzyl bromide

3-Methyl-2-o-tolyl-oxazolidine

Downstream raw materials:

o-Xylyl-<2-hydroxy-aethyl>-dimethylammonium-iodid

N-(2-hydroxyethyl)-N-(methoxycarbonylmethyl)-N-methyl-N-(2-methylbenzyl)ammonium bromide