109-83-1

Basic information

• Product Name: 2-Methylaminoethanol
• Synonyms: N-METHYLETHANOLAMINE;N-METHYL(B-HYDROXYETHYL)AMINE;METHYLETHYLOLAMINE;Methylethanolamine;AKOS BBS-00004409;2-(METHYLAMINO)ETHANOL;(2-Hydroxyethyl)methylamine;(Hydroxyethyl)methylamine
• CAS NO: 109-83-1
• Molecular Formula: C₃H₉NO
• Molecular Weight: 75.11
• EINECS: 203-710-0
• Mol File: 109-83-1.mol
• Article Data: 75

Chemical Properties

• Melting Point: -3 °C
• Boiling Point: 159 °C(lit.)
• Flash Point: 163 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 0.935 g/mL at 25 °C(lit.)
• Vapor Density: 2.6 (vs air)
• Vapor Pressure: 0.5 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.439(lit.)
• Storage Temp.: Store below +30°C.
• PKA: pK1:9.88(＋1) (25°C)
• Explosive Limit: 1.6-17.7%(V)
• Water Solubility: miscible
• Stability: Stable. Combustible. Incompatible with oxidizing agents.
• Merck: 14,6015
• BRN: 1071196
• CAS DataBase Reference: 2-Methylaminoethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylaminoethanol(109-83-1)
• EPA Substance Registry System: 2-Methylaminoethanol(109-83-1)

Safety Data

• Hazard Codes: C
• Statements: 21/22-34-48/22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 1
• RTECS: KL6650000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 109-83-1(Hazardous Substances Data)

Usage

Chemical Properties

viscous colourless or light yellow liquid

Uses

Different sources of media describe the Uses of 109-83-1 differently. You can refer to the following data:
1. Textile chemicals, pharmaceuticals.
2. 2-(Methylamino)ethanol is used as an intermediate in synthetic chemistry. It finds application in various fields such as textile lubricants, polishes, detergents and in personal care products. It is also involved in electrostatic automotive coatings and in acid gas scrubbing. Further, it serves as an intermediate in polymers and pharmaceuticals. In addition to this, it is used as a solvent in the natural gas-processing industry.

Definition

ChEBI: An ethanolamine compound having an N-methyl substituent.

Production Methods

Monomethylethanolamine is manufactured by reacting ethylene oxide and methylamine with external cooling.

General Description

A clear colorless liquid. Flash point 165°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.

Air & Water Reactions

Soluble in water.

Reactivity Profile

2-Methylaminoethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 2-Methylaminoethanol may react with oxidizing materials.

Health Hazard

Exposure can cause irritation of eyes, nose and throat.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes such as NOx. See also AMINES and ALCOHOLS.

InChI:InChI=1/C3H9NO/c1-4-2-3-5/h4-5H,2-3H2,1H3/p+1

Synthetic route

oxirane (75-21-8) + methylamine (74-89-5) → (2-hydroxyethyl)(methyl)amine (109-83-1) + N-Methyldiethanolamine (105-59-9) + 2,2'-((1-hydroxypropan-2-yl)azanediyl)bis(ethan-1-ol) (68998-54-9)

Conditions	Yield
water at 62.84 - 71.84℃; under 7500.75 Torr; for 0.2h; Heating / reflux;	A 16.7% B 83.3% C n/a
at 66.84 - 76.84℃; under 9000.9 Torr; for 0.116667h; Heating / reflux;	A 63.5% B 36.4% C 0.02%
water at 61.54 - 63.34℃; under 7500.75 Torr; for 0.2h; Heating / reflux;
at 66.34℃; under 9000.9 Torr; for 0.116667h; Heating / reflux;

2-(N-benzyl-N-methyl)amino-1-ethanol (101-98-4) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.166667h; Heating;	83%
With hydrogen; Pd/C (5percent) In ethanol at 20℃; for 2h;	67%
With hydrazine hydrate; palladium on activated charcoal In ethanol for 2h; Heating;	42%

4-methyl-1-oxa-4-azaspiro<4.5>decane (39931-24-3) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 1-methyl-4,5,6,7-tetrahydro-1H-indole (51265-33-9) + cyclohexanol (108-93-0)

Conditions	Yield
With potassium hydroxide Heating; CH3ONa sa reagent;	A n/a B 72% C n/a

formaldehyd (50-00-0) + ethanolamine (141-43-5) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
Stage #1: formaldehyd; ethanolamine With zinc(II) chloride In dichloromethane at 20℃; for 1h; Stage #2: With sodium tetrahydroborate In dichloromethane for 18h;	72%
Stage #1: formaldehyd; ethanolamine Stage #2: With sodium tetrahydroborate

ethanolamine (141-43-5) + dimethyl sulfate (77-78-1) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With methyllithium In tetrahydrofuran for 1h; Product distribution; Ambient temperature; further reagents investigated;	66%

ethylene glycol (107-21-1) + methylamine (74-89-5) → N,N'-dimethylpiperazine (106-58-1) + (2-hydroxyethyl)(methyl)amine (109-83-1) + N,N`-dimethylethylenediamine (110-70-3)

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; tris(triphenylphosphine)ruthenium(II) chloride at 130℃; Product distribution; Mechanism; other primary amines, other temperatures, other catalyst;	A 33% B 4% C 44%

oxirane (75-21-8) + methylamine (74-89-5) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
In ethanol; water at 30 - 40℃;	30%

oxazol (288-42-6) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With potassium hydroxide; aluminum nickel for 26.1h;	28%

methanol (67-56-1) + ethanolamine (141-43-5) → ethyleneimine (151-56-4) + piperazine (110-85-0) + 1,4-diaza-bicyclo[2.2.2]octane (280-57-9) + (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With Cs-P-Si mixed-oxide at 300℃; under 750.06 Torr; Title compound not separated from byproducts;	A 37 % Chromat. B n/a C n/a D 6%

methanol (67-56-1) + ethanolamine (141-43-5) → piperazine (110-85-0) + 1,4-diaza-bicyclo[2.2.2]octane (280-57-9) + (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With H-β-zeolite at 250℃; under 750.06 Torr; Title compound not separated from byproducts;	A n/a B n/a C 2%

4,5-epoxy-3-methoxy-17-methyl-morphin-6-en-8-one (94713-16-3) + acetic anhydride (108-24-7) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 1,5-diacetoxy-4-[2-(acetyl-methyl-amino)-ethyl]-6-methoxy-phenanthrene (7463-47-0)

(+-)-thebaine (115-37-7, 23979-17-1, 23979-19-3) + sodium acetate (127-09-3) + acetic anhydride (108-24-7) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 3,6-Dimethoxy-4-acetoxyphenanthrene (47192-97-2)

oxirane (75-21-8) + methylamine (74-89-5) → (2-hydroxyethyl)(methyl)amine (109-83-1) + N-Methyldiethanolamine (105-59-9)

Conditions	Yield
unter starker Kuehlung;

N-methylaziridine (1072-44-2) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With sulfuric acid

pyridine (110-86-1) + 2-(N,N-dimethylamino)ethanol (108-01-0) + dibenzoyl peroxide (94-36-0) → (2-hydroxyethyl)(methyl)amine (109-83-1) + formaldehyd (50-00-0)

sarcosine (107-97-1) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride

Sarcosine ethyl ester (13200-60-7) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With ethanol; nickel at 100℃; under 257428 Torr; Hydrogenation;

methyl-carbamic acid-(2-chloro-ethyl ester) (22074-92-6) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With potassium hydroxide
With sodium hydroxide und nachfolgendes Aufbewahren oder Erwaermen auf 90-100grad;

2-(methyl-piperonyl-amino)-ethanol (91247-76-6) + acetic anhydride (108-24-7) → (2-hydroxyethyl)(methyl)amine (109-83-1) + piperonol (495-76-1)

Conditions	Yield
nachfolgend Erhitzen mit alkoh. Kalilauge;

ethyl 2-(benzyloxycarbonylamino)ethanoate (1145-81-9) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride

thebaine (115-37-7) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With benzoyl chloride at 0℃;
With sodium acetate; acetic anhydride durch Spaltung;

formaldehyd (50-00-0) + ethanolamine (141-43-5) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 2-(N,N-dimethylamino)ethanol (108-01-0)

Conditions	Yield
durch unter azeotropem Abdestillieren des gebildeten Wassers mit Benzol und Hydrierung des Reaktionsprodukts an Raney-Nickel bei 80grad/140 at;

tertamethylammonium iodide (75-58-1) + ethanolamine (141-43-5) → (2-hydroxyethyl)(methyl)amine (109-83-1) + trimethylamine (75-50-3)

Conditions	Yield
at 154℃; Rate constant;

methylamine (74-89-5) + 2-chloro-ethanol (107-07-3) → (2-hydroxyethyl)(methyl)amine (109-83-1)

Conditions	Yield
With water at 110℃;
In ethanol at 25℃; for 15h;

acetic anhydride (108-24-7) + 4,5-epoxy-3-methoxy-17-methyl-morphin-7-en-6-one (467-13-0, 65494-91-9, 105815-00-7) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 4,6-diacetoxy-3-methoxy-phenanthrene (16654-23-2)

2-(4-methylphenyl)-2,3-dimethyl-1,3-oxazolidine (78456-50-5) → (2-hydroxyethyl)(methyl)amine (109-83-1) + dimethyl sulfate (77-78-1)

Conditions	Yield
With sodium hydroxide; acetic acid buffer In acetonitrile at 25℃; Rate constant; Mechanism; var. time, var. buffer, var. pH;

ethanolamine (141-43-5) + dimethyl sulfate (77-78-1) → (2-hydroxyethyl)(methyl)amine (109-83-1) + 2-(N,N-dimethylamino)ethanol (108-01-0)

Conditions	Yield
With calcium hydride 1.) THF, room temp., 1 h; 2.) room temp, 1 h; Yield given. Multistep reaction;
With lithium hydride 1.) THF, room temp., 1 h; 2.) room temp., 1 h; Yield given. Multistep reaction;

(2-Hydroxy-ethyl)-methyl-prop-(E)-ylidene-ammonium; perchlorate → (2-hydroxyethyl)(methyl)amine (109-83-1) + propionaldehyde (123-38-6)

Conditions	Yield
With perchloric acid at 10.1℃; Kinetics; Thermodynamic data; ΔH(excit.); -ΔS(excit.); solvent deuterium isotope effects; different temperatures;

Eth-(E)-ylidene-(2-hydroxy-ethyl)-methyl-ammonium; perchlorate → (2-hydroxyethyl)(methyl)amine (109-83-1) + acetaldehyde (75-07-0)

Conditions	Yield
With perchloric acid at 10.1℃; Kinetics; Thermodynamic data; ΔH(excit.); -ΔS(excit.); different temperatures;

(2-hydroxyethyl)(methyl)amine (109-83-1) → 1-bromo-2-(N-methylamino)ethane hydrobromide (40052-63-9)

Conditions	Yield
With sulfurous dibromide; N,N-dimethyl-formamide In toluene at 50℃;	100%
With hydrogen bromide at 4 - 123℃;	83%
With hydrogen bromide In water at 4℃;	60.4%

(2-hydroxyethyl)(methyl)amine (109-83-1) + acrylic acid methyl ester (292638-85-8) → N-(2-hydroxy-ethyl)-N-methyl-β-alanine methyl ester (20517-44-6)

Conditions	Yield
for 3h; Sonication; Schlenk technique; Inert atmosphere;	100%
With methanol

(2-hydroxyethyl)(methyl)amine (109-83-1) → 2-chloro-3-methyl-1-oxa-3-aza-2-phosphacyclopentane 2-oxide (66046-61-5)

Conditions	Yield
With triethylamine; trichlorophosphate In dichloromethane for 17h; Ambient temperature;	100%
With triethylamine; trichlorophosphate In chloroform at 25 - 30℃; for 0.5h;	86%
With triethylamine; trichlorophosphate In dichloromethane
With triethylamine; trichlorophosphate In diethyl ether at 0℃; for 2h;
With triethylamine In dichloromethane

(2-hydroxyethyl)(methyl)amine (109-83-1) + di-tert-butyl dicarbonate (24424-99-5) → methyl(2-hydroxyethyl)carbamic acid tert-butyl ester (57561-39-4)

Conditions	Yield
In acetonitrile at 20℃; Condensation;	100%
In dichloromethane at 20℃; for 1h;	100%
In tetrahydrofuran at 20℃; for 4h;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + epichlorohydrin (106-89-8) → 1-Chlor-2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-amino-propan (63125-83-7)

Conditions	Yield
at 40 - 70℃;	100%
In water at 13 - 34℃; for 1.41667h;
In isopropyl alcohol

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2,5-dibromopyridine (624-28-2) → 2-[(5-bromopyridin-2-yl)methylamino]ethanol (149806-47-3)

Conditions	Yield
at 150℃; for 18h;	100%
potassium fluoride on basic alumina for 0.25h; microwave irradiation;	86%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2-chloro-5-(5-methylfuran-2-yl)pyridine (718639-02-2) → 2-{methyl[5-(5-methylfuran-2-yl)pyridin-2-yl]amino}ethanol (718639-13-5)

Conditions	Yield
for 24h; Heating;	100%

4-chloro-6-(4-methoxyphenoxy)pyrimidine (607723-54-6) + (2-hydroxyethyl)(methyl)amine (109-83-1) → 2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethanol (607723-69-3)

Conditions	Yield
In ethanol Heating;	100%
In N,N-dimethyl-formamide at 80℃; Temperature; Solvent; Large scale;	1.66 kg

4-chloro-6-(3,4-dimethoxyphenoxy)pyrimidine (869639-13-4) + (2-hydroxyethyl)(methyl)amine (109-83-1) → 2-{[6-(3,4-dimethoxyphenoxy)pyrimidin-4-yl]methylamino}ethanol (869639-16-7)

Conditions	Yield
In ethanol Heating;	100%

4-(biphenyl-4-yloxy)-6-chloropyrimidine (607723-59-1) + (2-hydroxyethyl)(methyl)amine (109-83-1) → 2-{[6-(biphenyl-4-yloxy)pyrimidin-4-yl]methylamino}ethanol (607723-75-1)

Conditions	Yield
In ethanol Heating;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-chloro-6-(4-fluorophenoxy)pyrimidine (124041-01-6) → 2-{[6-(4-fluorophenoxy)pyrimidin-4-yl]methylamino}ethanol (607723-67-1)

Conditions	Yield
In ethanol Heating;	100%

4,8-di-tert-butyl-2,10-dimethyl-6-propa-1,2-dienyl-12H-5,7-dioxa-6-phospha-dibenzo[a,d]cyclooctene 6-oxide + (2-hydroxyethyl)(methyl)amine (109-83-1) → 2-{[2-(4,8-di-tert-butyl-2,10-dimethyl-6-oxo-12H-5,7-dioxa-6λ5-phospha-dibenzo[a,d]cycloocten-6-yl)-1-methyl-vinyl]-methyl-amino}-ethanol

Conditions	Yield
In acetonitrile at 25℃; for 4h;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + trans-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-acetic acid → trans [2-(4-{[(2-hydroxy-ethyl)-methyl-carbamoyl]-methyl}-cyclohexyl)-ethyl]-methyl-carbamic acid tert-butyl ester

Conditions	Yield
With N-ethylmorpholine;; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate at 20℃; for 3h;	100%
With N-ethylmorpholine;; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate at 20℃; for 3h;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-methoxy-2,6-dimethylbenzenesulfonyl chloride (55661-08-0) → N-(2-hydroxyethyl)-4-methoxy-2,6,N-trimethylbenzenesulphonamide (766558-31-0)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 15h;	100%
With triethylamine In dichloromethane at 20℃; for 15h;	99%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 1-bromomethyl-4-bromobenzene (589-15-1) → 2-[(4-bromo-benzyl)-methyl-amino]-ethanol (918642-06-5)

Conditions	Yield
In 1,2-dimethoxyethane at 40℃; for 1h;	100%
With potassium carbonate In acetonitrile at 20℃; for 2h;

(2-hydroxyethyl)(methyl)amine (109-83-1) + 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxylic acid ethyl ester (1071504-75-0, 1071504-73-8, 1071504-74-9) → N-(2-hydroxyethyl)-N-methyl-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-carboxamide (1071504-81-8)

Conditions	Yield
at 20 - 70℃; for 120.24h; Product distribution / selectivity;	100%
at 20 - 70℃; for 110.25h; Product distribution / selectivity;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) → 2-(methylamino)ethan-1-ol hydrochloride (62640-03-3)

Conditions	Yield
With hydrogenchloride In water at 20℃; for 2h;	100%
With hydrogenchloride In water

(2-hydroxyethyl)(methyl)amine (109-83-1) + 3-(bromomethyl)benzonitrile (28188-41-2) → 3-{[(2-hydroxyethyl)methylamino]methyl}benzonitrile (1141474-62-5)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 1-[2-[(chloromethyl)phenyl]ethyl]-3,5,7,9,11,13,15-heptacyclopentylpentacyclo[9.5.1.13,9.15,15.17,13]octasiloxane (1023524-14-2) → C47H81NO13Si8 (1234502-87-4)

Conditions	Yield
With pyridine In dichloromethane for 24h; Reflux; Inert atmosphere;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + methyl dithioacetate (2168-84-5) → 2-hydroxy-N-methylethanethioamide (69394-45-2)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 15h; Inert atmosphere;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + (4-nitro-1H-pyrazol-5-yl)methanol → 2-(methyl((4-nitro-1H-pyrazol-5-yl)methyl)amino)ethanol

Conditions	Yield
Stage #1: (4-nitro-1H-pyrazol-5-yl)methanol With carbon tetrabromide; triphenylphosphine In dichloromethane at 0℃; for 1.33333h; Stage #2: (2-hydroxyethyl)(methyl)amine With N-ethyl-N,N-diisopropylamine In dichloromethane at 10℃; for 1h;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 1,9-dichloro-5-phenyldipyrromethene (1394285-00-7) → 9-chloro-1-((N-2-hydroxyethyl-N-methyl)amino)-5-phenyldipyrrin

Conditions	Yield
With triethylamine In acetonitrile at 70℃; for 57h; Inert atmosphere;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + ethyl acrylate (140-88-5) → N-Methyl-N-(2-hydroxyethyl)-β-alanin-ethylester (10494-78-7)

Conditions	Yield
In neat (no solvent) at 20℃; Michael Addition; Inert atmosphere;	100%

(2-hydroxyethyl)(methyl)amine (109-83-1) + p-(chloromethyl)benzoyl chloride (876-08-4) → 4-(chloromethyl)-N-(2-hydroxyethyl)-N-methylbenzamide (1182906-72-4)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 10℃; for 0.166667h; Solvent; Reagent/catalyst;	100%

2-chloropyridine (109-09-1) + (2-hydroxyethyl)(methyl)amine (109-83-1) → 2-(N-methyl-N-(pyridin-2-yl)amino)ethanol (122321-04-4)

Conditions	Yield
for 9h; Reflux;	99%
With triphenylmethyl sodium at 70℃; for 8h; Temperature;	97%
at 140℃; for 0.333333h; Sealed vessel; Neat (no solvent);	92%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-(3-bromoanilino)-7-fluoropyrido[4,3-d]pyrimidine (171178-25-9) → 2-{[4-(3-Bromo-phenylamino)-pyrido[4,3-d]pyrimidin-7-yl]-methyl-amino}-ethanol

Conditions	Yield
In iso-butanol at 100℃; for 48h;	99%

(2-hydroxyethyl)(methyl)amine (109-83-1) + tris(hydroxymethyl)phosphine (2767-80-8) → tris(N-2-hydroxyethyl-N-methylaminomethyl)phosphine

Conditions	Yield
In water at 20℃; for 1h; Condensation;	99%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-chloro-6-methoxy-pyrimidine (26452-81-3) → 2-[(6-methoxypyrimidin-4-yl)methylamino]ethanol (869639-14-5)

Conditions	Yield
In ethanol for 24h; Heating;	99%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 3,4-difluoronitrobenzene (369-34-6) → 2-[2-Fluoro(methyl)-4-nitroanilino]ethanol (677727-07-0)

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 1.5h;	99%
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃; for 24h;	79%

Upstream product

• 1098-29-9 1-[(E)-1-bromo-2-(4-methoxyphenyl)-2-phenylethenyl]-2-fluorobenzene 
• 109829-32-5 2-ethoxyethyl (2Z)-3-[(4-chlorobenzyl)amino]-2-cyanopent-2-enoate 
• 109828-61-7 1,1,2,2,9,9,10,10-Octamethyl-1,2,9,10-tetrasila(2.2)paracyclophane 
• 109828-23-1 1,2,4,5-tetrachloro-3-(2,4,5-trichlorophenoxy)benzene 
• 109828-22-0 1,2,3,4-tetrachloro-5-(3,4-dichlorophenoxy)benzene 
• 1098-27-7 4-iodo-2,5,7-trinitro-9H-fluoren-9-one 
• 109827-56-7 DIAZIRAN-1-YL[2-(TRICHLOROMETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]PHOSPHINE SULFIDE 
• 109826-59-7 BUTTPARK 23\07-01 
• 109826-53-1 11-DEOXY-13,14-DIHYDRO-15-KETO-11BETA,16CHI-CYCLOPROSTAGLANDIN E2 
• 109826-27-9 CGS 9343B 
• 109826-26-8 Zaldaride 
• 109825-81-2 4-tert-butyl-2,6-dinitro-N-(2,4,6-trichlorophenyl)aniline 
• 109825-55-0 2-tert-butyl-4,6-dinitro-N-[4-(trifluoromethyl)phenyl]aniline 
• 109825-52-7 2,4,6-tribromo-N-(2-tert-butyl-4,6-dinitrophenyl)aniline 

Downstream Products

• 59702-07-7 1-Methylpiperazin-2-one 
• 4318-37-0 N-Methylhomopiperazine 

Recommend Products

• 75-21-8  oxirane 
• 74-89-5  methylamine 
• 105-59-9  N-Methyldiethanolamine 
• 1072-44-2  N-methylaziridine 
• 50-00-0  formaldehyd 
• 110-86-1  pyridine 
• 108-01-0  2-(N,N-dimethylamino)ethanol 
• 94-36-0  dibenzoyl peroxide 
• 122320-81-4  2-(methyl-thiazol-2-yl-amino)-ethanol 
• 3034-53-5  2-bromo-1,3-thiazole 
• 107-97-1  sarcosine 
• 22074-92-6  methyl-carbamic acid-(2-chloro-ethyl ester) 
• 286-20-4  cyclohexane-1,2-epoxide 
• 1630-62-2  3-methyl-2-phenyl-oxazolidine 

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Hydrogen bonding and conformational equilibrium of 2-Methylaminoethanol (cas 109-83-1) by microwave spectroscopy08/20/2019

From its microwave spectrum, 2-methylaminoethanol is found to exist in two rotameric forms, each having an intramolecular hydrogen bond of the type OH⋯N and a gauche OCCN configuration. The lower energy form (GT) has rotational constants (MHz) A = 12123.35 (31), B = 2653.774 (15), and C = 2400...detailed