corynoxeine

Base Information

Chemical Name:corynoxeine
CAS No.:630-94-4
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:2933998090

Synonyms:Corynoxan-16-carboxylicacid, 16,17,18,19-tetradehydro-17-methoxy-2-oxo-, methyl ester, (7b,16E,20a)-;Corynoxeine (6CI,7CI);Corynoxein;Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-, methyl ester, [1'R-[1'a,6'b,7'a(E),8'ab]]-;D18-Rhyncophylline;d18-Rhynchophylline;Corynoxeine;(+/-)-corynoxeine;ISOCORYNOXEINE;

Suppliers and Price of corynoxeine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Corynoxeine
20mg
$ 490.00

TRC
Corynoxeine
5mg
$ 330.00

Medical Isotopes, Inc.
Corynoxeine 98%
20 mg
$ 517.00

DC Chemicals
Corynoxeine >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Corynoxeine 98+%
10mg
$ 210.00

Crysdot
Corynoxeine 98+%
5mg
$ 120.00

ChemScene
Corynoxeine 99.91%
10mg
$ 270.00

ChemScene
Corynoxeine 99.91%
5mg
$ 150.00

Biosynth Carbosynth
corynoxeine
10 mg
$ 100.00

Biosynth Carbosynth
corynoxeine
5 mg
$ 57.00

Total 54 raw suppliers

Chemical Property of corynoxeine

Chemical Property:

Appearance/Colour:white poweder
Vapor Pressure:1.09E-12mmHg at 25°C
Melting Point:210 oC
Refractive Index:1.605
Boiling Point:562.7°C at 760 mmHg
PKA:13.54±0.60(Predicted)
Flash Point:294.1°C
PSA：67.87000
Density:1.25
LogP:2.55210

Purity/Quality:

99%, ^*data from raw suppliers

Corynoxeine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Corynoxeine is an alkaloid isolated from extraction of Uncaria rhynchophylla, is useful in the treatment of vascular diseases and protection against ischemia-induced neuronal damage.

Technology Process of corynoxeine

There total 12 articles about corynoxeine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₂N₂O₄

: 865-47-4
potassium tert-butylate

: 4009-98-7
(methoxymethyl)triphenylphosphonium chloride

: 630-94-4,51014-29-0
(±)-corynoxeine

Guidance literature:: potassium tert-butylate; (methoxymethyl)triphenylphosphonium chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

C₂₀H₂₂N₂O₄; In tetrahydrofuran; at -78 - 20 ℃;

With trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/ejoc.201201505

Reference yield:

: C₂₅H₂₉N₃O₈S

: 630-94-4,51014-29-0
(±)-corynoxeine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thiophenol; potassium carbonate / dimethyl sulfoxide / 2.15 h

2.1: triethylamine / acetonitrile / 2.33 h / 20 °C

3.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

4.1: 6 h / 0 °C

5.1: tetrahydrofuran / 0.08 h / 20 °C

5.2: -78 - 20 °C

With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; 5.2: |Wittig Olefination;
DOI:10.1002/ejoc.201201505

Reference yield:

: 1443767-64-3
C₁₉H₂₆N₂O₄

: 630-94-4,51014-29-0
(±)-corynoxeine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 2.33 h / 20 °C

2.1: caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 8 h / Inert atmosphere

3.1: 6 h / 0 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

4.2: -78 - 20 °C

With bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; acetonitrile; 4.2: |Wittig Olefination;
DOI:10.1002/ejoc.201201505