3-(3-methoxyphenoxy)propanenitrile

Base Information

• Chemical Name: 3-(3-methoxyphenoxy)propanenitrile
• CAS No.: 6279-84-1
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 2926907090
• Mol file: 6279-84-1.mol

Synonyms:

Chemical Property of 3-(3-methoxyphenoxy)propanenitrile

Chemical Property:

• Vapor Pressure: 0.000139mmHg at 25°C
• Melting Point: 29.5-30.5 °C
• Boiling Point: 333.2°C at 760 mmHg
• Flash Point: 135.7°C
• PSA: 42.25000
• Density: 1.081g/cm³
• LogP: 1.98768

Purity/Quality:

99%, ^*data from raw suppliers

3-(3-Methoxyphenoxy)propanenitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-methoxyphenoxy)propanenitrile

There total 4 articles about 3-(3-methoxyphenoxy)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

O-methylresorcine (150-19-6) + acrylonitrile (107-13-1,25014-41-9) → β-(m-methoxyphenoxy)propionitrile (6279-84-1)

Guidance literature:

With triton; In methanol;

DOI:10.1071/CH07325

Reference yield:

O-methylresorcine (150-19-6) → β-(m-methoxyphenoxy)propionitrile (6279-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 6 h / 120 °C

2: 18-crown-6 / acetonitrile / 24 h / Heating

With sodium hydroxide; 18-crown-6 ether; In acetonitrile;

Reference yield:

1-(2-bromoethoxy)-3-methoxybenzene (3245-45-2) + potassium cyanide (151-50-8) → β-(m-methoxyphenoxy)propionitrile (6279-84-1)

Guidance literature:

With 18-crown-6 ether; In acetonitrile; for 24h; Yield given; Heating;

upstream raw materials:

O-methylresorcine

acrylonitrile

1-(2-bromoethoxy)-3-methoxybenzene

potassium cyanide

Downstream raw materials:

7,3',4'-trimethoxyflavanone

4',7-dimethoxyflavanone

7-methoxyflavanone

5-methoxyflavanone

Refernces

• 1、 Cho, Yang Yil,Jang, Hyu Jeong,Kim, Dong Hwan,Kim, Nam Yong,Kim, Nam-Jung,Kim, Young Min,Lee, Soo Jin,Lee, Yong Sup,Park, Boyoung Y.,Son, Seung Hwan,Yoo, Hyung-Seok. "Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids". supporting information. p. 10012 - 10023. Retrieved 2019/08/30.
• 2、 Lai, Steven M. F.,Orchison, Jack J. A.,Whiting, Donald A.. "A NEW SYNTHETIC APPROACH TO THE ROTENOID RING SYSTEM". . p. 5895 - 5906. Retrieved 2007/10/02.