N-(6-chloropyridin-3-yl)acetamide

Base Information

• Chemical Name: N-(6-chloropyridin-3-yl)acetamide
• CAS No.: 29958-18-7
• Molecular Formula: C7H7 Cl N2 O
• Molecular Weight: 170.598
• Hs Code.: 2933399090
• NSC Number: 170622
• DSSTox Substance ID: DTXSID60305386
• Wikidata: Q82052013
• Mol file: 29958-18-7.mol

Synonyms:29958-18-7;5-Acetamido-2-chloropyridine;N-(6-chloropyridin-3-yl)acetamide;NSC170622;SCHEMBL5629234;DTXSID60305386;AKOS017355313;NSC-170622;SB53674;BS-27872;CS-0083326;F2199-0278

Chemical Property of N-(6-chloropyridin-3-yl)acetamide

Chemical Property:

• Vapor Pressure: 2.55E-05mmHg at 25°C
• Boiling Point: 358.4°C at 760 mmHg
• Flash Point: 170.6°C
• PSA: 41.99000
• Density: 1.336g/cm³
• LogP: 1.76640
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Acetamido-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CN=C(C=C1)Cl

Technology Process of N-(6-chloropyridin-3-yl)acetamide

There total 3 articles about N-(6-chloropyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-Chloro-pyridin-3-ylamine (5350-93-6) + 2-chloro-5-(N-methylacetamido)pyridine + acetyl chloride (75-36-5) → 5-acetamido-2-chloropyridine (29958-18-7)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

6-Chloro-pyridin-3-ylamine (5350-93-6) → 5-acetamido-2-chloropyridine (29958-18-7)

Guidance literature:

Reference yield:

→ 5-acetamido-2-chloropyridine (29958-18-7)

Guidance literature:

2-Chlor-5-nitro-pyridin, (CH3CO)2O, H2;

DOI:10.1039/j39710003257

upstream raw materials:

6-Chloro-pyridin-3-ylamine

acetyl chloride

Downstream raw materials:

5-acetamido-2-N-benzylaminopyridine