4-Aminomorpholine

Base Information

• Chemical Name: 4-Aminomorpholine
• CAS No.: 4319-49-7
• Molecular Formula: C4H10N2O
• Molecular Weight: 102.136
• Hs Code.: 29349990
• European Community (EC) Number: 224-347-4
• NSC Number: 6825
• UNII: LG90NXJ1BP
• DSSTox Substance ID: DTXSID60195769
• Nikkaji Number: J24.480E
• Wikidata: Q72439814
• Mol file: 4319-49-7.mol

Synonyms:4-Aminomorpholine;N-Aminomorpholine;4319-49-7;4-Morpholinamine;morpholin-4-amine;Morpholin-4-ylamine;MORPHOLINE, 4-AMINO-;4-Morpholinamine (9CI);NSC 6825;EINECS 224-347-4;LG90NXJ1BP;BRN 0103145;NSC-6825;4-27-00-00623 (Beilstein Handbook Reference);morpholine-4-ylamine;N-amino morpholine;N-amino-morpholine;4-amino morpholine;4-amino-morpholine;4-aminomorph-oline;morpholine-4-amine;morpholin-4-yl-amine;4-MORPHOLINEAMINE;UNII-LG90NXJ1BP;4-Aminomorpholine, 97%;SCHEMBL42607;SCHEMBL43686;(MORPHOLIN-4-YL)AMINE;DTXSID60195769;NSC6825;4-Aminomorpholine N-Aminomorpholine;STR00551;BBL027563;MFCD00006174;STL169269;AKOS000120329;CS-W001074;PS-9309;LS-92396;A0832;BB 0263212;FT-0617582;EN300-20556;A826214;A937468;W-106240;F0001-1192

Chemical Property of 4-Aminomorpholine

Chemical Property:

• Appearance/Colour: Clear colorless to faintly yellow liquid
• Vapor Pressure: 1.65mmHg at 25°C
• Refractive Index: n20/D 1.4772(lit.)
• Boiling Point: 168 °C at 760 mmHg
• PKA: pK1: 4.19(+1) (25°C)
• Flash Point: 58.3 °C
• PSA: 38.49000
• Density: 1.062 g/cm³
• LogP: -0.16950
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Solubility.: Chloroform, Methanol (Slightly)
• Water Solubility.: miscible
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 102.079312947
• Heavy Atom Count: 7
• Complexity: 51.7

Purity/Quality:

99% ^*data from raw suppliers

4-Aminomorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn,F,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-23-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1N
• Uses: 4-Aminomorpholine can be used to prepare antiviral agents to prevent and treat influenza.

Technology Process of 4-Aminomorpholine

There total 14 articles about 4-Aminomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-nitrosomorpholine (59-89-2) → 1-aminomorpholine (4319-49-7)

Guidance literature:

With titanium(III) chloride; In water; for 1h; Ambient temperature;

DOI:10.1021/jo00193a007

Reference yield: 31.0%

N-nitrosomorpholine (59-89-2) → 1-aminomorpholine (4319-49-7) + N,N'-bis(morpholino)diazene (57902-11-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 10 ℃; for 3h; 1) R_.T_., 1 h 2) reflux, 3 h;

Reference yield:

morpholine (110-91-8,99108-56-2) → 1-aminomorpholine (4319-49-7)

Guidance literature:

With chloroamine;

DOI:10.1021/jo01093a602 DOI:10.1021/ja01616a061

upstream raw materials:

morpholine

N-nitrosomorpholine

N,N-di(2-hydroxyethyl)hydrazine

3-oxa-1,5-dichloropentane

Downstream raw materials:

Morpholin-4-yl-(1-phenethyl-piperidin-4-ylidene)-amine

1-(2-aminobenzamido)morpholine

7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-(4-morpholinylimino)-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

3-Methyl-3-morpholinoamino-N-(4-chlorphenyl)acrylamid

Refernces

• 1、 Wu, Yachuang,Ding, Xiudong,Ding, Liang,Zhang, Yongsheng,Cui, Lei,Sun, Lu,Li, Wei,Wang, Di,Zhao, Yanfang. "Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents". . p. 247 - 258. Retrieved 2018/09/18.
• 2、 Brehme, Rainer. "Aza-enamines, VIII. - Electrophilic Substitution reactions at the Azomethine C-Atom of Aldehyde Dialkylhydrazones: Vilsmeier Formylation and Consecutive Reactions". . p. 2039 - 2046. Retrieved 2007/10/02.