N,N'-Bis(2-methoxyphenyl)guanidine

Base Information

• Chemical Name: N,N'-Bis(2-methoxyphenyl)guanidine
• CAS No.: 6268-03-7
• Molecular Formula: C15H17N3O2
• Molecular Weight: 271.319
• NSC Number: 37143
• UNII: I75KL19QFE
• DSSTox Substance ID: DTXSID20211732
• Nikkaji Number: J343.570I
• ChEMBL ID: CHEMBL310729
• Mol file: 6268-03-7.mol

Synonyms:N,N'-Bis(2-methoxyphenyl)guanidine;Di-o-anisylguanidine;GUANIDINE, N,N'-BIS(2-METHOXYPHENYL)-;6268-03-7;I75KL19QFE;CHEMBL310729;NSC 37143;NSC-37143;BRN 3387288;NSC37143;UNII-I75KL19QFE;SCHEMBL2286441;DTXSID20211732;1,3-bis(2-methoxyphenyl)guanidine;BDBM50010745;LS-73277;N,N''-Bis-(2-methoxy-phenyl)-guanidine;3-13-00-00812 (Beilstein Handbook Reference)

Chemical Property of N,N'-Bis(2-methoxyphenyl)guanidine

Chemical Property:

• Vapor Pressure: 3.44E-08mmHg at 25°C
• Boiling Point: 447.1°C at 760 mmHg
• Flash Point: 224.2°C
• Density: 1.15g/cm³
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 271.132076794
• Heavy Atom Count: 20
• Complexity: 322

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1NC(=NC2=CC=CC=C2OC)N

Technology Process of N,N'-Bis(2-methoxyphenyl)guanidine

There total 11 articles about N,N'-Bis(2-methoxyphenyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-iodoanisol (529-28-2) + guanidine nitrate (506-93-4) → N,N'-bis(2-methoxyphenyl)-Guanidine (6268-03-7)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N-diethylsalicylamide; In acetonitrile; at 80 ℃; Inert atmosphere;

DOI:10.1021/ol1002175

Reference yield: 35.0%

bromocyane (506-68-3) + 2-methoxy-phenylamine (90-04-0) → N,N'-bis(2-methoxyphenyl)-Guanidine (6268-03-7)

Guidance literature:

In ethanol; at 150 ℃; for 0.5h;

DOI:10.1021/jm00171a016

Reference yield:

methyl thiocyanate (556-64-9) + 2-methoxy-phenylamine (90-04-0) → N,N'-bis(2-methoxyphenyl)-Guanidine (6268-03-7)

Guidance literature:

With lead acetate; at 110 ℃;

upstream raw materials:

1,3-bis-(2-methoxy-phenyl)-thiourea

N,N'-bis-(2-methoxy-phenyl)-S-methyl-isothiourea

methyl thiocyanate

2-methoxy-phenylamine

Downstream raw materials:

2-methoxyacetanilide