3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acrylamide

Base Information

• Chemical Name: 3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acrylamide
• CAS No.: 121817-65-0
• Molecular Formula: C21H25 N O5
• Molecular Weight: 371.433
• Mol file: 121817-65-0.mol

Synonyms:2-Propenamide,3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-, (E)-; Rubemamine;trans-Rubemamine

Chemical Property of 3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acrylamide

Chemical Property:

• PSA: 66.02000
• LogP: 3.48400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acrylamide

There total 5 articles about 3-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,4-dimethoxy-trans-cinnamic acid (14737-89-4) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → (E)-N-(3,4-dimethoxyphenethyl)-3-(3,4-dimethoxyphenyl)acrylamide (121817-65-0)

Guidance literature:

3,4-dimethoxy-trans-cinnamic acid; With tris(2,2,2-trifluoroethyl) borate; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Green chemistry;

2-(3,4-dimethoxyphenyl)-ethylamine; In acetonitrile; at 100 ℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1016/j.ejps.2018.10.028

Reference yield:

3,4-dimethoxy-trans-cinnamic acid (14737-89-4) → (E)-N-(3,4-dimethoxyphenethyl)-3-(3,4-dimethoxyphenyl)acrylamide (121817-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / SOCl₂ / 0.5 h / 100 °C

2: aq. NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

With thionyl chloride; sodium hydrogencarbonate; In chloroform; water;

DOI:10.1016/0031-9422(89)80125-6

Reference yield:

3,4-dimethoxyphenylacetonitrile (93-17-4) → (E)-N-(3,4-dimethoxyphenethyl)-3-(3,4-dimethoxyphenyl)acrylamide (121817-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / COCl₂*6H₂O, NaBH₄ / methanol / 2 h / Ambient temperature

2: aq. NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

With sodium tetrahydroborate; sodium hydrogencarbonate; cobalt(II) chloride; In methanol; chloroform; water;

DOI:10.1016/0031-9422(89)80125-6

upstream raw materials:

(E)-3,4-dimethoxycinnamic chloride

2-(3,4-dimethoxyphenyl)-ethylamine

3,4-dimethoxy-trans-cinnamic acid

3,4-dimethoxyphenylacetonitrile