Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride

Base Information

Chemical Name:Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride
CAS No.:93851-85-5
Molecular Formula:C19H24ClNO3
Molecular Weight:349.8518
Hs Code.:
DSSTox Substance ID:DTXSID10917493

Synonyms:93851-85-5;Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride;2-(alpha-(o-Ethoxyphenoxy)benzyl)morpholine hydrochloride;Morpholine, 2-((2-ethoxyphenoxy)phenylmethyl)-, hydrochloride;2-[(2-Ethoxyphenoxy)(phenyl)methyl]morpholine hydrochloride;DTXSID10917493;LS-93000;2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine;hydrochloride;2-[(2-Ethoxyphenoxy)(phenyl)methyl]morpholine--hydrogen chloride (1/1)

Suppliers and Price of Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride

Chemical Property:

Vapor Pressure:4.54E-08mmHg at 25°C
Boiling Point:443.7°C at 760 mmHg
Flash Point:188.2°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:349.1444713
Heavy Atom Count:24
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3.Cl

Technology Process of Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride

There total 10 articles about Morpholine, 2-(alpha-(o-ethoxyphenoxy)benzyl)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94-71-3
2-Ethoxyphenol

: 93851-85-5
2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

9: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;

Reference yield:

: 93852-37-0
(2-Ethoxy-phenoxy)-phenyl-acetic acid

: 93851-85-5
2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 16 h / Ambient temperature

2: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

3: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

4: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

5: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

6: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

7: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 93851-85-5
2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

9: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;