Technology Process of CID 5207899
There total 8 articles about CID 5207899 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
para-methylphenylmagnesium bromide;
With
zinc dimethoxide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
2-bromo-2-cyclopentylacetonitrile;
With
(1,2-dimethoxyethane)dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; (4R,4'R)-2,2'-(cyclopentane-1,1-diyl)bis(4-isopropyl-4,5-dihydrooxazole);
In
tetrahydrofuran;
at -78 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja303442q
- Guidance literature:
-
para-methylphenylmagnesium bromide;
With
zinc dimethoxide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
2-bromo-2-cyclopentylacetonitrile;
With
(1,2-dimethoxyethane)dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; (4S,4'S)-2,2'-(cyclopentane-1,1-diyl)bis(4-iso-propyl-4,5-dihydrooxazole);
In
tetrahydrofuran;
at -78 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja303442q
- Guidance literature:
-
With
potassium tert-butylate; C38H42Ir2N4O2;
In
neat (no solvent);
at 120 ℃;
for 1h;
Inert atmosphere;
Glovebox;
DOI:10.1021/acs.joc.0c02400
