Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide

Base Information

• Chemical Name: Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide
• CAS No.: 128156-78-5
• Molecular Formula: C₁₈H₁₉ClN₂O₃
• Molecular Weight: 346.813
• DSSTox Substance ID: DTXSID60155828
• Wikidata: Q83023809
• Mol file: 128156-78-5.mol

Synonyms:BRN 4329030;Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide;alpha-Hydroxy-4-methyl-alpha-(4-methylphenyl)benzeneacetic acid 2-(chloroacetyl)hydrazide;128156-78-5;DTXSID60155828;LS-28847

Chemical Property of Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 346.1084202
• Heavy Atom Count: 24
• Complexity: 420

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(C2=CC=C(C=C2)C)(C(=O)NNC(=O)CCl)O

Technology Process of Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide

There total 2 articles about Benzeneacetic acid, alpha-hydroxy-4-methyl-alpha-(4-methylphenyl)-, 2-(chloroacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Hydroxy-di-p-tolyl-acetic acid hydrazide (84408-85-5) + chloroacetyl chloride (79-04-9) → Chloro-acetic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide (128156-78-5)

Guidance literature:

In 1,4-dioxane; for 2h; Heating;

DOI:10.1007/BF00764409

Reference yield:

di-p-tolylglycolic acid cyclohexylidenehydrazide (119845-08-8) → Chloro-acetic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide (128156-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / hydrazine hydrate / ethanol / 0.25 h / Heating

2: 70 percent / dioxane / 2 h / Heating

With hydrazine hydrate; In 1,4-dioxane; ethanol;

DOI:10.1007/BF00764409

Reference yield: 74.0%

Chloro-acetic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide (128156-78-5) + 2-Bromopropionyl chloride (7148-74-5) → 2-Bromo-propionic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide (128156-82-1)

Guidance literature:

In 1,4-dioxane; for 2h; Heating;

DOI:10.1007/BF00764409

upstream raw materials:

Hydroxy-di-p-tolyl-acetic acid hydrazide

chloroacetyl chloride

di-p-tolylglycolic acid cyclohexylidenehydrazide

Downstream raw materials:

2-Bromo-propionic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide

2-Diethylamino-propionic acid N'-(2-hydroxy-2,2-di-p-tolyl-acetyl)-hydrazide

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