3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol

Base Information Edit

Chemical Name:3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol
CAS No.:27298-75-5
Molecular Formula:C9H18 N O2
Molecular Weight:172.247
Hs Code.:
DSSTox Substance ID:DTXSID00514591
Mol file:27298-75-5.mol

Synonyms:3-(HYDROXYMETHYL)-1-OXY-2,2,5,5-TETRAMETHYLPYRROLIDINE;3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol;1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl-;1020718-52-8;(1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)methanol;SCHEMBL4853121;DTXSID00514591;AKOS030255294;FT-0669834;J-016721

Suppliers and Price of 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(Hydroxymethyl)-1-oxy-2,2,5,5-tetramethylpyrrolidine
50mg
$ 515.00

Total 7 raw suppliers

Chemical Property of 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol Edit

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Melting Point:112-113°C
Boiling Point:257.302°C at 760 mmHg
Flash Point:108.361°C
PSA：43.70000
Density:1.006g/cm³
LogP:1.18490
Storage Temp.:-20°C Freezer
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:173.141578849
Heavy Atom Count:12
Complexity:177

Purity/Quality:

99% ^*data from raw suppliers

3-(Hydroxymethyl)-1-oxy-2,2,5,5-tetramethylpyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC(C(N1O)(C)C)CO)C
General Description 1-Pyrrolidinyloxy, 3-(hydroxymethyl)-2,2,5,5-tetramethyl- (also known as HM-PROXYL or Hydroxymethyl-proxyl) is a nitroxide radical with moderate lipophilicity, as indicated by its partition coefficient (K_p), which falls between that of more hydrophilic (CxP, CmP) and more lipophilic (MCP) analogs. Pharmacokinetic studies show that it exhibits a biphasic decay in blood levels, with a slower reduction rate compared to other probes like MCP. Its moderate lipophilicity allows for distribution to peripheral tissues, including the brain, while its slower reduction rate contributes to a higher area under the curve (AUC) compared to more lipophilic counterparts. Unlike hydrophilic probes, which are primarily excreted renally, HM-PROXYL's behavior is influenced by both its partitioning properties and redox stability, making it a useful probe for in vivo magnetic resonance studies.

Technology Process of 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol

There total 8 articles about 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%