Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate

Base Information

Chemical Name:Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate
CAS No.:40674-21-3
Molecular Formula:C14H15 N O5
Molecular Weight:277.277
Hs Code.:2925190090
European Community (EC) Number:255-030-9
DSSTox Substance ID:DTXSID20193660
Nikkaji Number:J294.728E
Wikidata:Q83066412
ChEMBL ID:CHEMBL2272247
Mol file:40674-21-3.mol

Synonyms:40674-21-3;Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate;ethyl 2-(1,3-dioxoisoindol-2-yl)oxy-2-methylpropanoate;Ethyl 2-(N-phthalimidooxy)-2-methylpropionate;EINECS 255-030-9;Ethyl 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-methylpropanoate;ETHYL 2-[(1,3-DIHYDRO-1,3-DIOXO-2H-ISOINDOL-2-YL)OXY]-2-METHYLPROPIONATE;Propanoic acid,2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-methyl-, ethyl ester;CHEMBL2272247;SCHEMBL14587496;DTXSID20193660;BS-49198;CS-0528860;FT-0745079;2-(Phthalimidyloxy)isobutyric acid ethyl ester;E85395;W-110937;Ethyl 2-(1,3-dioxo-1,3-dihydro-2-isoindolyloxy)-2-methylpropionate;Propanoic acid, 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methyl-, ethyl ester

Suppliers and Price of Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alfa Aesar
Ethyl 2-(N-phthalimidooxy)-2-methylpropionate, 98%
1g
$ 137.00

Alfa Aesar
Ethyl 2-(N-phthalimidooxy)-2-methylpropionate, 98%
250mg
$ 46.10

Total 8 raw suppliers

Chemical Property of Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate

Chemical Property:

Vapor Pressure:3.23E-06mmHg at 25°C
Boiling Point:387.7°Cat760mmHg
Flash Point:188.3°C
PSA：72.91000
Density:1.3g/cm³
LogP:1.49380
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:277.09502258
Heavy Atom Count:20
Complexity:407

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-(N-phthalimidooxy)-2-methylpropionate, 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)(C)ON1C(=O)C2=CC=CC=C2C1=O

Technology Process of Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate

There total 4 articles about Ethyl 2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 600-00-0
ethyl 2-bromoisobutyrate

: 524-38-9
N-hydroxyphthalimide

: 40674-21-3
2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)-2-methylpropionic acid ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 35 ℃; for 72h;

Reference yield: 64.0%

: 524-38-9
N-hydroxyphthalimide

: 97-62-1
Ethyl isobutyrate

: 40674-21-3
2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)-2-methylpropionic acid ethyl ester

Guidance literature:: With di-tert-butyl peroxide; In benzene; at 150 ℃; for 3h; Solvent; Reagent/catalyst; Sealed tube; Darkness;
DOI:10.1021/acs.joc.9b02656