2-AMino-6-(butylaMino)pyriMidin-4-ol

Base Information

• Chemical Name: 2-AMino-6-(butylaMino)pyriMidin-4-ol
• CAS No.: 60462-37-5
• Molecular Formula: C₈H₁₄N₄O
• Molecular Weight: 182.225
• Mol file: 60462-37-5.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-6-(butylamino)- (9CI); 4-Pyrimidinol, 2-amino-6-(butylamino)- (7CI);NSC 52443

Chemical Property of 2-AMino-6-(butylaMino)pyriMidin-4-ol

Chemical Property:

• Vapor Pressure: 0.000203mmHg at 25°C
• Boiling Point: 327.4°Cat760mmHg
• Flash Point: 151.8°C
• PSA: 83.80000
• Density: 1.3g/cm³
• LogP: 1.21830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-6-(butylaMino)pyriMidin-4-ol

There total 2 articles about 2-AMino-6-(butylaMino)pyriMidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-chloroisocytosine (1194-21-4) + N-butylamine (109-73-9,85404-21-3) → 2-amino-6-butylamino-3H-pyrimidin-4-one (60462-37-5)

Guidance literature:

In ethanol; for 4h; Reflux;

Reference yield:

→ 2-Amino-4-oxy-6-butylamino-pyrimidin (60462-37-5)

Guidance literature:

6-Chlor-2-amino-4-hydroxy-pyrimidin, Butylamin, HO-CH2-CH2-O-C2H5, Siedetemp.;

Reference yield:

2-amino-6-butylamino-3H-pyrimidin-4-one (60462-37-5) → 9-n-butylguanine (93905-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂, aq. AcOH

2: 90percent aq. HCO₂H, Na₂S₂O₄ / Heating

With formic acid; sodium dithionite; acetic acid; sodium nitrite;

DOI:10.1021/jm00074a025

upstream raw materials:

6-chloroisocytosine

N-butylamine

Downstream raw materials:

9-n-butylguanine

Refernces

• 1、 Michael,Cottam,Smee,Robins,Kini. "Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines.". . p. 3431 - 3436. Retrieved 2007/10/02.