1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine

Base Information

Chemical Name:1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine
CAS No.:5957-84-6
Molecular Formula:C12H8 F3 N
Molecular Weight:223.197
Hs Code.:
DSSTox Substance ID:DTXSID60974975
Wikidata:Q82959458

Synonyms:1-cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine;CBMicro_038843;Oprea1_536266;Oprea1_711167;DTXSID60974975;AKOS000548366;CCG-311428;BIM-0038756.P001

Suppliers and Price of 1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine

Chemical Property:

Vapor Pressure:2.27E-06mmHg at 25°C
Boiling Point:392.6°Cat760mmHg
Flash Point:110.2°C
Density:1.064g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:288.220163521
Heavy Atom Count:21
Complexity:296

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1CN2CCN(CC2)C3CCCCC3

Technology Process of 1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine

There total 19 articles about 1-Cyclohexyl-4-[(2-methoxyphenyl)methyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 109-04-6
2-bromo-pyridine

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 5957-84-6
2-(3-trifluoromethylphenyl)pyridine

Guidance literature:: 3-bromo-1-trifluoromethylbenzene; With ethylene dibromide; trifluoroacetic acid; cobalt(II) bromide; zinc; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere; Sealed tube;

2-bromo-pyridine; With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile; at 50 ℃; for 1h; Inert atmosphere; Sealed tube;
DOI:10.1002/chem.201903414

Reference yield: 92.0%

: 109-04-6
2-bromo-pyridine

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 5957-84-6
2-(3-trifluoromethylphenyl)pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 5h; Schlenk technique; Inert atmosphere; Reflux;
DOI:10.1039/d0ob00484g

Reference yield: 88.0%

: 1219454-89-3
2-((difluoromethyl)sulfonyl)pyridine

: 401-81-0
m-trifluoromethylphenyl iodide

: 5957-84-6
2-(3-trifluoromethylphenyl)pyridine

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; nickel dichloride; zinc; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Schlenk technique;
DOI:10.1021/acs.orglett.0c03939