2-Amino-3-bromo-5-methylpyridine

Base Information

• Chemical Name: 2-Amino-3-bromo-5-methylpyridine
• CAS No.: 17282-00-7
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 29333999
• Mol file: 17282-00-7.mol

Synonyms:5-Bromo-3-methyl-1H-pyridin-6-amine;2-Amino-3-bromo-5-picoline;2-Amino-5-methyl-3-bromo pyridine;

Chemical Property of 2-Amino-3-bromo-5-methylpyridine

Chemical Property:

• Appearance/Colour: light brown solid
• Vapor Pressure: 0.0194mmHg at 25°C
• Melting Point: 73-76 °C(lit.)
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 252.348 °C at 760 mmHg
• PKA: 4.28±0.49(Predicted)
• Flash Point: 106.417 °C
• PSA: 38.91000
• Density: 1.593 g/cm³
• LogP: 2.31590
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-bromo-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-3-bromo-5-methylpyridine is used for the preparation of imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines, and imidazo[1,2-d]triazines as JNK and ERK kinase inhibitors 2-Amino-3-bromo-5-methylpyridine may be used in the synthesis of:3-bromo-2-chloro-5-methylpyridine3-bromo-2-fluoro-5-methylpyridine8-methyl-1,2,3,5-tetrahydropyrido[3,4-b][1,4]diazepin-4-one3-bromo-2-(ethylamino)-5-methylpyridine(3-bromo-5-methylpyridin-2-yl)aniline5-methyl-3-(phenylethynyl)pyridin-2-amine3-[(2-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine3-[(4-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine3-[(3-chlorophenyl)ethynyl]-5-methylpyridin-2-amine

Technology Process of 2-Amino-3-bromo-5-methylpyridine

There total 2 articles about 2-Amino-3-bromo-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 3-bromo-5-methylpyridin-2-amine (17282-00-7)

Guidance literature:

With bromine; sodium acetate; acetic acid; at 20 ℃;

DOI:10.1016/j.bmc.2015.03.073

Reference yield:

→ 3-bromo-5-methylpyridin-2-amine (17282-00-7)

Guidance literature:

Reference yield: 100.0%

3-bromo-5-methylpyridin-2-amine (17282-00-7) + (3,4-difluorophenyl)boronic acid (168267-41-2) → 3-(3,4-difluorophenyl)-5-methylpyridin-2-amine (1340487-51-5)

Guidance literature:

With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

Downstream raw materials:

8-bromo-6-methyl-imidazo<1,2-a>pyridine

3-Bromo-5-methyl-2-nitro-pyridine

2-amino-5-methyl-3-pyridine carbonitrile

5-Methyl-3-(4-methylsulfanyl-phenyl)-pyridin-2-ylamine