1-(4-Methoxyphenyl)-4-phenylazetidin-2-one

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)-4-phenylazetidin-2-one
• CAS No.: 19340-68-2
• Molecular Formula: C16H15 N O2
• Molecular Weight: 253.301
• Mol file: 19340-68-2.mol

Synonyms:2-Azetidinone,1-(p-methoxyphenyl)-4-phenyl- (8CI);1-(4-Methoxyphenyl)-4-phenylazetidin-2-one; NSC 519846

Chemical Property of 1-(4-Methoxyphenyl)-4-phenylazetidin-2-one

Chemical Property:

• Vapor Pressure: 5.63E-10mmHg at 25°C
• Boiling Point: 496°Cat760mmHg
• Flash Point: 253.8°C
• PSA: 29.54000
• Density: 1.2g/cm³
• LogP: 3.23820

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Methoxyphenyl)-4-phenylazetidin-2-one

There total 25 articles about 1-(4-Methoxyphenyl)-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-phenylazetidin-2-one (5661-55-2) + para-iodoanisole (696-62-8) → 1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (19340-68-2)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.9b04768

Reference yield: 82.0%

4-methoxy-N-[(1Z)-phenylmethylene]aniline (40339-42-2) + ethyl bromoacetate (105-36-2) → 1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (19340-68-2)

Guidance literature:

With zinc; iodine; In 1,4-dioxane; at 25 ℃; for 5h; ultrasonication;

DOI:10.1039/c39840000086

Reference yield: 80.0%

S-2-pyridyl ethanethioate (10111-76-9) + [4-(benzylideneamino)phenyl]methanol (783-08-4) → 1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (19340-68-2)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at 0 ℃; for 3h;

upstream raw materials:

ethyl β-(4-methoxyanilino)-β-phenylpropionate

acetic anhydride

trans-bromo-1-p-methoxyphenyl-4-phenyl-2-azetidinone

[4-(benzylideneamino)phenyl]methanol

Downstream raw materials:

6-methoxy-4-phenyl-3,4-dihydroquinolin-2(1H)-one

(2E)-N-(4-methoxyphenyl)cinnamamide

trans-3-hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one

C₃₈H₅₁N₃O₅S