Chemical Property of 2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.669
- Boiling Point:580.841 °C at 760 mmHg
- PKA:2.02±0.10(Predicted)
- Flash Point:305.082 °C
- PSA：109.85000
- Density:1.433 g/cm3
- LogP:3.51740
- Storage Temp.:Store at RT
- Solubility.:Limited solubility, soluble in DMSO
- XLogP3:-0.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:353.12632271
- Heavy Atom Count:26
- Complexity:559
- Purity/Quality:
-
99%, *data from raw suppliers
LY-341495 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C(C1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
- Isomeric SMILES:C1[C@@H]([C@H]1[C@@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
-
Uses
LY 341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively). In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2. LY341495 can be effectively used in isolated cells, tissues, and in vivo. In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.[Cayman Chemical] LY-341495 is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist.
