(1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

Base Information

• Chemical Name: (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester
• CAS No.: 175415-91-5
• Molecular Formula: C₁₅H₂₄O₄
• Molecular Weight: 268.353

Synonyms:(1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

Chemical Property of (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

There total 3 articles about (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1R,2R)-cyclopropane-1,2-dicarboxylic acid bis-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester (96149-01-8) → (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester (175415-91-5)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol; at 70 ℃;

DOI:10.1021/ja0205232

Reference yield:

C19H32O4 → (1S,2S)‐2‐((((1S,2R,5S)‐2‐isopropyl‐5‐methylcyclohexyl)oxy)carbonyl)cyclopropane‐1‐carboxylic acid + (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester (175415-91-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h; Overall yield = 10.3 g;

DOI:10.1246/bcsj.20190168

Reference yield:

bis((2R,1S,5S)-2-isopropyl-5-methylcyclohexyl)succinate (96149-05-2) → (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester (175415-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / 2,2,6,6-tetramethylpiperidine; n-butyllitium / tetrahydrofuran; hexane / 4 h / -78 °C

2: 92 percent / NaOH / propan-2-ol; H₂O / 70 °C

With 2,2,6,6-tetramethyl-piperidine; sodium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; water; isopropyl alcohol;

DOI:10.1021/ja0205232

upstream raw materials:

(1R,2R)-cyclopropane-1,2-dicarboxylic acid bis-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

bis((2R,1S,5S)-2-isopropyl-5-methylcyclohexyl)succinate

Downstream raw materials:

(1R,2R)-2-chlorocarbonyl-cyclopropanecarboxylic acid (1S,2R,5S)-5-isopropyl-2-methyl-cyclohexyl ester

(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

(1R,2R)-2-[(R)-1-Benzenesulfonyl-4-(2,2-diphenyl-ethyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

(1R,2R)-2-[(S)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 175415-91-5 (1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send