1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol

Base Information

• Chemical Name: 1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
• CAS No.: 81228-35-5
• Molecular Formula: C₂₂H₃₀FNO₄
• Molecular Weight: 391.483
• Mol file: 81228-35-5.mol

Synonyms:1-(4-(2-(Fluorophenethyloxy)ethyl)phenoxy)-3-isopropylamino-2-propanol hcl;RO-31-1118;Ro 31-1411;Flusoxolol;2-Propanol, 1-(4-(2-(2-(4-fluorophenyl)ethoxy)ethoxy)phenoxy)-3-((1-methylethyl)amino)-, (+-)-;Ro 31-1118;

Chemical Property of 1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol

Chemical Property:

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol

There total 4 articles about 1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-Fluorophenyl)ethanol (7589-27-7) → Flusoxolol (81228-35-5,86941-24-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 10 min, 2.) DMF, 60 deg C, 30 min

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: pyridine / 0.5 h

4: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;

DOI:10.1021/jm00365a005

Reference yield:

<<2-(4-fluorophenyl)ethyl>oxy>acetic acid (81228-04-8) → Flusoxolol (81228-35-5,86941-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: pyridine / 0.5 h

3: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;

DOI:10.1021/jm00365a005

Reference yield:

4-Fluoro-1-[2-[2-hydroxyethoxy]ethyl]benzene (81228-11-7) → Flusoxolol (81228-35-5,86941-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; sodium hydride;

DOI:10.1021/jm00365a005

upstream raw materials:

prenalterol

2-<<2-(4-fluorophenyl)ethyl>oxy>ethyl methanesulfonate

2-(4-Fluorophenyl)ethanol

4-Fluoro-1-[2-[2-hydroxyethoxy]ethyl]benzene