H-80/62

Base Information

• Chemical Name: H-80/62
• CAS No.: 62340-37-8
• Molecular Formula: C12H19NO3
• Molecular Weight: 225.288
• Mol file: 62340-37-8.mol

Synonyms:1-(isopropylamino)-3-(4-hydroxyphenoxy)-2-propanol;1-(4-hydroxyphenoxy)-(2,S)-2-hydroxy-3-isopropylamino-propane;(-)-Varbian;1-(4-hydroxyphenoxy)-2-hydroxy-3-isopropylaminopropane;1-(4-hydroxyphenoxy)-3-isopropylaminopropan-2-ol;(-)-4-Hydroxyphenylisopropylamine;Racemic Prenalterol;(-)-Prenalterol;

Chemical Property of H-80/62

Chemical Property:

• Boiling Point: 397.7°Cat760mmHg
• Flash Point: 194.3°C
• PSA: 61.72000
• Density: 1.118g/cm³
• LogP: 1.52080

Purity/Quality:

> 95% ^*data from raw suppliers

4-[2-HYDROXY-3-(PROPAN-2-YLAMINO)PROPOXY]PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-80/62

There total 6 articles about H-80/62 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ICI 45849 hydrochloride (7695-79-6) → prenalterol (62340-37-8)

Guidance literature:

at 28 ℃; for 192h; Cunninghamella echinulata;

DOI:10.1002/jps.2600760220

Reference yield:

(+/-)-1-[p-(benzyloxy)phenoxy]-3-(isopropylamino)propan-2-ol (34380-47-7) → prenalterol (62340-37-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00304a018

Reference yield:

4-Benzyloxyphenol (103-16-2) → prenalterol (62340-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. NaOH, (ii) /BRN= 605259/

2: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00304a018

upstream raw materials:

(+/-)-1-isopropylamino-3-phenoxypropan-2-ol

ICI 45849 hydrochloride

(+/-)-1-[p-(benzyloxy)phenoxy]-3-(isopropylamino)propan-2-ol

4-Benzyloxyphenol

Downstream raw materials:

1-(isopropylamino)-3-<4-<(4-chloropyrazol-1-yl)methoxy>phenoxy>-2-propanol

1-Isopropylamino-3-[4-(2-phenethyloxy-ethoxy)-phenoxy]-propan-2-ol

1-[4-[2-(4-methylphenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Flusoxolol