Piperazine-1-carboxamide

Base Information

• Chemical Name: Piperazine-1-carboxamide
• CAS No.: 5623-95-0
• Molecular Formula: C5H11 N3 O
• Molecular Weight: 129.16
• Hs Code.: 2933599090
• NSC Number: 86952
• UNII: A78BU5W9Y2
• DSSTox Substance ID: DTXSID80293039
• Wikidata: Q82031601
• Mol file: 5623-95-0.mol

Synonyms:piperazine-1-carboxamide;5623-95-0;1-Piperazinecarboxamide;Piperazine-1-carboxylic acid amide;A78BU5W9Y2;NSC-86952;piperazinecarboxamide;piperazine amide;NSC86952;1-piperazine carboxamide;N-CARBAMOYLPIPERAZINE;1-CARBAMOYLPIPERAZINE;NCIOpen2_001195;UNII-A78BU5W9Y2;SCHEMBL242268;SCHEMBL5568742;DTXSID80293039;1-Piperazinecarboxamide AldrichCPR;HMS1696G18;1-Piperazinecarboxamide, AldrichCPR;NSC 86952;tetrahydropyrazine-1(2h)-carboxamide;AKOS000131730;PIPERAZINE, 1-(AMINOCARBONYL)-;BB 0241893;CS-0106301;FT-0677669;EN300-29919;D76637;A869988

Chemical Property of Piperazine-1-carboxamide

Chemical Property:

• Melting Point: 121 °C(Solv: benzene (71-43-2))
• Boiling Point: 254.5±50.0 °C(Predicted)
• PKA: 14.74±0.20(Predicted)
• PSA: 58.36000
• Density: 1.153±0.06 g/cm3(Predicted)
• LogP: -0.06270
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 129.090211983
• Heavy Atom Count: 9
• Complexity: 109

Purity/Quality:

98%min ^*data from raw suppliers

Piperazine-1-carboxylic acid amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C(=O)N

Technology Process of Piperazine-1-carboxamide

There total 3 articles about Piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-carbamoylpiperazine-1-carboxylate (588-88-5) → 1-piperazine carboxamide (5623-95-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.25h;

Reference yield:

→ 1-piperazine carboxamide (5623-95-0)

Guidance literature:

Reference yield:

→ 2,3-dimethyl-4-methanesulfonaminophenol + 1-piperazine carboxamide (5623-95-0)

Guidance literature:

upstream raw materials:

benzyl 4-carbamoylpiperazine-1-carboxylate

Downstream raw materials:

7-(oxiran-2-ylmethoxy)-2H-benzopyran-2-one

4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

4-{2-[4-(3-methoxy-benzoylamino)-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-ethyl}-piperazine-1-carboxylic acid amide

Refernces

• 1、 -. "CARBAMYLPIPERAZINE COMPOUNDS". . . Retrieved 2008/06/13.