4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

Base Information

Chemical Name:4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide
CAS No.:1436422-09-1
Molecular Formula:C₂₆H₃₀ClF₅N₆O₂
Molecular Weight:589.008
Hs Code.:

Synonyms:4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

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Chemical Property of 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

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Technology Process of 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

There total 5 articles about 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174632-70-2
4-(bromomethyl)-2,3-difluorobenzoic acid

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 5623-95-0
1-piperazine carboxamide

: 1436422-09-1
4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

Guidance literature:: 4-(bromomethyl)-2,3-difluorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

1-piperazine carboxamide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 261763-37-5
2,3-difluoro-4-methylbenzoic acid

: 1436422-09-1
4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 90 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 1 h / 20 °C / Cooling with ice

2.3: 1 h / 80 °C

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436422-09-1
4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3.1: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 1 h / 20 °C / Cooling with ice

4.3: 1 h / 80 °C

With oxalyl dichloride; ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;