3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone

Base Information

• Chemical Name: 3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone
• CAS No.: 78295-91-7
• Molecular Formula: C₁₄H₁₄FN₃O₃
• Molecular Weight: 291.282
• Mol file: 78295-91-7.mol

Synonyms:3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone

Chemical Property of 3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone

Chemical Property:

• Vapor Pressure: 6.53E-12mmHg at 25°C
• Boiling Point: 526.4°C at 760 mmHg
• Flash Point: 272.2°C
• PSA: 85.43000
• Density: 1.421g/cm³
• LogP: 1.16880

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone

There total 4 articles about 3-carboxy-4-oxo-6-fluoro-7-(1-piperazinyl)-1,4-dihydroquinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[(4-tert-butoxycarbonyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (908340-55-6) → ciprofloxacin (78295-91-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

DOI:10.1021/jm060010w

Reference yield:

1-(2-cyanoethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (908340-52-3) → ciprofloxacin (78295-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / dimethylsulfoxide / 18 h / 90 °C

2: 97 percent / aq. LiOH / ethanol / 4 h / Heating

3: aq. HCl / dioxane / 1 h

With hydrogenchloride; lithium hydroxide; In 1,4-dioxane; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm060010w

Reference yield:

7-[(4-tert-butoxycarbonyl)piperazin-1-yl]-1-(2-cyanoethyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (908340-53-4) → ciprofloxacin (78295-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / aq. LiOH / ethanol / 4 h / Heating

2: aq. HCl / dioxane / 1 h

With hydrogenchloride; lithium hydroxide; In 1,4-dioxane; ethanol;

DOI:10.1021/jm060010w

upstream raw materials:

7-[(4-tert-butoxycarbonyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-(2-cyanoethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

7-[(4-tert-butoxycarbonyl)piperazin-1-yl]-1-(2-cyanoethyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester