N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide

Base Information

Chemical Name:N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide
CAS No.:108401-70-3
Molecular Formula:C₁₃H₁₇N₃O₂
Molecular Weight:247.297
Hs Code.:
DSSTox Substance ID:DTXSID80910714

Synonyms:108401-70-3;N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide;2H-1,4-Benzoxazine-2-carboxamide, N,N-dimethyl-3-(dimethylamino)-;3-(Dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide [Italian];3-(Dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide;3-(dimethylamino)-N,N-dimethyl-2H-1,4-benzoxazine-2-carboxamide;DTXSID80910714;LS-41708

Suppliers and Price of N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide

Chemical Property:

Vapor Pressure:5.65E-07mmHg at 25°C
Boiling Point:411.3°C at 760 mmHg
Flash Point:202.5°C
Density:1.16g/cm³
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:247.132076794
Heavy Atom Count:18
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=NC2=CC=CC=C2OC1C(=O)N(C)C

Technology Process of N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide

There total 4 articles about N,N-Dimethyl-3-(dimethylamino)-2H-1,4-benzoxazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7313-22-6
N,N,N'N'-tetramethyl malonamide

: 108401-70-3
3-(dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide

Guidance literature:: Multi-step reaction with 4 steps

1: 86.5 percent / Br₂ / CCl₄ / 1.5 h / Heating; Irradiation

2: 78.2 percent / NaOH / H₂O; ethanol / 8 h / Heating

3: 97.9 percent / hydrogen / 5percent Pd/C / dioxane / 2128 Torr / Ambient temperature

4: 1.) POCl₃; 2.) sodium acetate / 1.) 1,2-dichloroethane, 20 min, r.t; 7.5 h, reflux; 2.) water, reflux, 1 h

With sodium hydroxide; hydrogen; bromine; sodium acetate; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; tetrachloromethane; ethanol; water;

Reference yield:

: 26727-15-1
2-bromo-N,N,N',N'-tetrametilmalonammide

: 108401-70-3
3-(dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide

Guidance literature:: Multi-step reaction with 3 steps

1: 78.2 percent / NaOH / H₂O; ethanol / 8 h / Heating

2: 97.9 percent / hydrogen / 5percent Pd/C / dioxane / 2128 Torr / Ambient temperature

3: 1.) POCl₃; 2.) sodium acetate / 1.) 1,2-dichloroethane, 20 min, r.t; 7.5 h, reflux; 2.) water, reflux, 1 h

With sodium hydroxide; hydrogen; sodium acetate; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;

Reference yield:

: 28043-50-7
N,N,N',N'-tetrametil-2-(2-nitrofenossi)malonammide

: 108401-70-3
3-(dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide

Guidance literature:: Multi-step reaction with 2 steps

1: 97.9 percent / hydrogen / 5percent Pd/C / dioxane / 2128 Torr / Ambient temperature

2: 1.) POCl₃; 2.) sodium acetate / 1.) 1,2-dichloroethane, 20 min, r.t; 7.5 h, reflux; 2.) water, reflux, 1 h

With hydrogen; sodium acetate; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane;