7313-22-6

Usage

Uses

Used in Pharmaceutical Industry:
N,N,N',N'-Tetramethylmalonamide is used as a chelating agent for the stabilization and complexation of metal ions in pharmaceutical formulations. Its ability to form stable complexes helps in enhancing the solubility and bioavailability of metal-based drugs, thereby improving their therapeutic efficacy.
Used in Analytical Chemistry:
In analytical chemistry, N,N,N',N'-Tetramethylmalonamide serves as a reagent for the synthesis of organic compounds and as a chelating agent in the analysis and detection of metal ions. Its strong complexing ability allows for accurate and sensitive measurements in various analytical techniques.
Used in Nuclear Fuel Reprocessing:
N,N,N',N'-Tetramethylmalonamide is utilized as a chelating agent in the reprocessing of nuclear fuel. It forms stable complexes with radioactive metal ions, facilitating their separation, recovery, and safe handling during the reprocessing of spent nuclear fuel.
Used in Rare Earth Element Extraction:
N,N,N',N'-TETRAMETHYLMALONAMIDE is employed as a solvent in the extraction of rare earth elements. Its water solubility and chelating properties enable the efficient separation and purification of rare earth elements from their ores, which are crucial for various high-tech applications.

Upstream product

• 3585-33-9 lithium dimethylamide 
• 105-53-3 diethyl malonate 
• 27433-12-1 2-methoxy-4H-pyrido[1,2-a]pyrimidin-4-one 
• 124-40-3 dimethyl amine 
• 108202-42-2 ((methyl)3tin)2C(CON(methyl)2)2 
• 504-64-3 carbon suboxide 
• 993-50-0 (dimethylamino)trimethyltin 
• 34057-61-9 1,3-dichloro-1,3-bis(dimethylamino)propenium chloride 
• 1663-67-8 malonoyl dichloride 
• 141-82-2 malonic acid 
• 7114-39-8 [1,3,2]dioxaphospholan-2-yl-dimethyl-amine 

Downstream Products

• 108401-70-3 3-(dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide 
• 28043-50-7 N,N,N',N'-tetrametil-2-(2-nitrofenossi)malonammide 
• 108401-65-6 2-(2-amminofenossi)-N,N,N',N'-tetrametilmalonammide 
• 849407-36-9 2-(dimethylamino)-3,6-dinitro-8-(4'-nitrophenyl)chromone 
• 35299-76-4 3-(dimethylamino)-1H-naphtho[2,1-b]pyran-1(4H)-one 
• 83767-03-7 2-(dimethylamino)-8-phenylchromone 
• 34656-64-9 Malonsaeure-dimethylamid- 

Relevant academic research and scientific papers

Synthesis of fluorinated malonamides and use in L/L extraction of f-elements

Synthesis of new fluorinated tertiary malonamides (F-malonamides) was accomplished, and their liquid/liquid (L/L) extraction properties with f-elements were investigated. These molecules are fluorinated analogues of well known extractants used in several processes designed towards the treatment of nuclear wastes, and the efficient separation of lanthanides from minor actinides; however, the synthesis of F-malonamides deserved a modification of the general synthetic route commonly employed to prepare H-malonamides. Extraction of neodymium from various aqueous media into both fluorous and classical solvents was studied, which revealed an opposite trend between F-malonamides and H-malonamides: L/L extraction ability is very sensitive to the nitrogen atoms substitution pattern, and the most efficient F-malonamide is compound 3 (R1 = Me), whereas the best H-malonamide is compound 5 (R1 = Bu, DMDBTDMA).

(2-Pyridyl)iminopropadienone

(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.

A simple general method for conversion of functionalized esters to functionalized amides

An efficient and easy new method for the conversion of amino-esters into amino-amides is described. In a one pot reaction between dialkyllithium amide and some amino-esters of thiophene and benzene, the corresponding amino-N-dialkylamides have been synthesized in high yields. The method was extended to malonic and phenylacetic esters. The reaction mechanism involves an anionic intermediate characterized by germylation.

MONO- AND DI-ADDITION PRODUCTS OF CARBON SUBOXIDE WITH ORGANO-TIN AMIDO COMPOUNDS

Carbon suboxide reacts with R3Sn-NMe2 (molar ratios 1:1 and 1:2) giving compounds, whose main features are presented, resulting from mono- and bis-addition of R3Sn-NMe2 across the C=C of C3O2

Preparation of New Vicinal Tricarbonyl Compounds and Some of Their Sulfur Analogues

Mesoxalamides 5, benzoylglyoxylamides 19, and pivaloylglyoxylamides 26 are prepared from the corresponding malonamides 4, benzoylacetamides 17 and pivaloylacetamides 24, respectively, by suitable oxidation reactions.Some of the sulfur analogues of 5,19, a