7313-22-6

Basic information

• Product Name: N,N,N',N'-TETRAMETHYLMALONAMIDE
• Synonyms: N,N,N',N'-TETRAMETHYLMALONAMIDE;N,N,N',N'-Tetramethylmalonamide
• CAS NO: 7313-22-6
• Molecular Formula: C₇H₁₄N₂O₂
• Molecular Weight: 158.2
• Mol File: 7313-22-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 160 °C / 10mmHg
• Appearance: /
• Density: 1,1 g/cm3
• Refractive Index: 1.4910-1.4940
• CAS DataBase Reference: N,N,N',N'-TETRAMETHYLMALONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N',N'-TETRAMETHYLMALONAMIDE(7313-22-6)
• EPA Substance Registry System: N,N,N',N'-TETRAMETHYLMALONAMIDE(7313-22-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 7313-22-6(Hazardous Substances Data)

Usage

General Description

N,N,N',N'-Tetramethylmalonamide is a chemical compound used as a complexing agent in various chemical and biological processes. It is a strong, water-soluble chelating agent that forms stable complexes with various metal ions, making it useful in industries such as pharmaceuticals, analytical chemistry, and nuclear fuel reprocessing. It is also used as a reagent for the synthesis of organic compounds and as a solvent for the extraction of rare earth elements. N,N,N',N'-Tetramethylmalonamide is a versatile chemical with a wide range of applications due to its ability to form stable complexes with metal ions and its solubility in water.

Upstream product

• 7114-39-8 [1,3,2]dioxaphospholan-2-yl-dimethyl-amine 
• 105-53-3 diethyl malonate 
• 993-50-0 (dimethylamino)trimethyltin 
• 3585-33-9 lithium dimethylamide 
• 27433-12-1 2-methoxy-4H-pyrido[1,2-a]pyrimidin-4-one 
• 124-40-3 dimethyl amine 
• 108202-42-2 ((methyl)3tin)2C(CON(methyl)2)2 
• 504-64-3 carbon suboxide 
• 34057-61-9 1,3-dichloro-1,3-bis(dimethylamino)propenium chloride 
• 1663-67-8 malonoyl dichloride 
• 141-82-2 malonic acid 

Downstream Products

• 108401-70-3 3-(dimetilammino)-N,N-dimetil-2H-1,4-benzossazin-2-carbossammide 
• 28043-50-7 N,N,N',N'-tetrametil-2-(2-nitrofenossi)malonammide 
• 108401-65-6 2-(2-amminofenossi)-N,N,N',N'-tetrametilmalonammide 
• 849407-36-9 2-(dimethylamino)-3,6-dinitro-8-(4'-nitrophenyl)chromone 
• 35299-76-4 3-(dimethylamino)-1H-naphtho[2,1-b]pyran-1(4H)-one 
• 83767-03-7 2-(dimethylamino)-8-phenylchromone 
• 34656-64-9 Malonsaeure-dimethylamid- 

Relevant articles and documents

Synthesis of fluorinated malonamides and use in L/L extraction of f-elements

Synthesis of new fluorinated tertiary malonamides (F-malonamides) was accomplished, and their liquid/liquid (L/L) extraction properties with f-elements were investigated. These molecules are fluorinated analogues of well known extractants used in several processes designed towards the treatment of nuclear wastes, and the efficient separation of lanthanides from minor actinides; however, the synthesis of F-malonamides deserved a modification of the general synthetic route commonly employed to prepare H-malonamides. Extraction of neodymium from various aqueous media into both fluorous and classical solvents was studied, which revealed an opposite trend between F-malonamides and H-malonamides: L/L extraction ability is very sensitive to the nitrogen atoms substitution pattern, and the most efficient F-malonamide is compound 3 (R1 = Me), whereas the best H-malonamide is compound 5 (R1 = Bu, DMDBTDMA).

A simple general method for conversion of functionalized esters to functionalized amides

An efficient and easy new method for the conversion of amino-esters into amino-amides is described. In a one pot reaction between dialkyllithium amide and some amino-esters of thiophene and benzene, the corresponding amino-N-dialkylamides have been synthesized in high yields. The method was extended to malonic and phenylacetic esters. The reaction mechanism involves an anionic intermediate characterized by germylation.

Preparation of New Vicinal Tricarbonyl Compounds and Some of Their Sulfur Analogues

Mesoxalamides 5, benzoylglyoxylamides 19, and pivaloylglyoxylamides 26 are prepared from the corresponding malonamides 4, benzoylacetamides 17 and pivaloylacetamides 24, respectively, by suitable oxidation reactions.Some of the sulfur analogues of 5,19, a