2-methyl-1,6-dioxaspiro[4.4]nonane

Base Information

• Chemical Name: 2-methyl-1,6-dioxaspiro[4.4]nonane
• CAS No.: 5451-15-0
• Molecular Formula: C8H14O2
• Molecular Weight: 142.198
• Hs Code.: 2932999099
• Mol file: 5451-15-0.mol

Synonyms:

Chemical Property of 2-methyl-1,6-dioxaspiro[4.4]nonane

Chemical Property:

• Vapor Pressure: 1.05mmHg at 25°C
• Boiling Point: 183.6°C at 760 mmHg
• Flash Point: 62.3°C
• PSA: 18.46000
• Density: 1.03g/cm³
• LogP: 1.69200

Purity/Quality:

99% ^*data from raw suppliers

2-METHYL-1,6-DIOXASPIRO[4.4]NONANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-methyl-1,6-dioxaspiro[4.4]nonane, a chemical compound, has limited but important applications in various fields. In the field of organic chemistry, it serves as a building block and a synthetic intermediate for the creation of complex organic molecules. Chemists use it to design and synthesize compounds with unique structures and properties, contributing to academic research and the development of new chemical methodologies. Its role is primarily centered around its utility as a versatile precursor for constructing diverse molecular architectures. While its applications are relatively niche, its significance lies in advancing the frontiers of organic chemistry and providing tools for researchers to explore new chemical reactions and compounds.

Technology Process of 2-methyl-1,6-dioxaspiro[4.4]nonane

There total 70 articles about 2-methyl-1,6-dioxaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(furan-2-yl)but-3-en-2-one (623-15-4) → 4-tetrahydrofuran-2-yl-butan-2-ol (3208-43-3,4527-76-8) + 2-methyl-1,6-dioxa-spiro[4.4]nonane (5451-15-0)

Guidance literature:

With 5% active carbon-supported ruthenium; hydrogen; In cyclohexane; at 100 ℃; for 2h; under 15001.5 Torr; Pressure; Solvent; Temperature; Reagent/catalyst; Autoclave;

DOI:10.1039/c9gc02555c

Reference yield: 80.0%

7-benzyloxy-1-hydroxy-oct-5-yn-4-one → 2-methyl-1,6-dioxa-spiro[4.4]nonane (5451-15-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 17h; under 760 Torr;

DOI:10.1021/ol047987k

Reference yield: 61.0%

1-methyl-3-heptyne-1,7-diol (126680-15-7) → 2-methyl-1,6-dioxa-spiro[4.4]nonane (5451-15-0)

Guidance literature:

With (1,3-bis{2,6-dimethyl-4-[(triethylammonio)methyl]phenyl}imidazolidin-2-yl)gold(I) chloride; In water; at 40 ℃; for 5h; Reagent/catalyst; Optical yield = 33.333 %de;

DOI:10.1002/ejoc.201403153

upstream raw materials:

4-(furan-2-yl)but-3-en-2-one

3-(5-methyl-2-furanyl)-1-propanol

4-(Dimethyl-hydrazono)-octane-1,7-diol

(E)-4-(furan-2-yl)but-3-en-2-one

Downstream raw materials:

(2R,5S)-2-methyl-1,6-dioxaspiro[4.4]nonane

(2S,5S)-2-methyl-1,6-dioxaspiro[4.4]nonane

(2R,5R)-2-methyl-1,6-dioxaspiro[4.4]nonane

(2S,5R)-2-methyl-1,6-dioxaspiro[4.4]nonane