6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-

Base Information

Chemical Name:6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-
CAS No.:149378-57-4
Molecular Formula:C28H23 N O8
Molecular Weight:501.493
Hs Code.:

Synonyms:6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-, (?à)-; (?à)-Lamellarin L; Lamellarin L; Lamellarine L

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Chemical Property of 6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-

There total 62 articles about 6H-[1]Benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one,8,9-dihydro-3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 271243-11-9
8,9-dihydro-3,11-diisopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4′,3′:4,5]pyrrolo[2,1-α]isoquinolin-6-one

: 149378-57-4
3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-8,9-dihydro-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo-[2,1-a]isoquinolin-6-one

Guidance literature:: With boron trichloride; In n-heptane; dichloromethane; at -78 - 20 ℃;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 149378-57-4
3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-8,9-dihydro-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo-[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 96 percent / potassium carbonate / dimethylsulfoxide / 2 h / 55 °C

2.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 81 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

3.1: 77 percent / sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 4 h / Heating

4.1: sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 18 h / Heating

4.2: 95 percent / hydrochloric acid / methanol / 1 h / Heating

5.1: KOH / H₂O; ethanol / 3 h / Heating

5.2: 91 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 1 h / Heating

6.1: 99 percent / copper(I) oxide; quinoline / 0.12 h / 220 °C

7.1: 90 percent / phenyliodine bis(trifluoroacetate); BF₃*OEt₂ / CH₂Cl₂ / 1.5 h / -40 °C

8.1: 98 percent / boron trichloride / CH₂Cl₂; heptane / -78 - 20 °C

With quinoline; copper(I) oxide; potassium hydroxide; boron trifluoride diethyl etherate; tert.-butyl lithium; boron trichloride; sodium carbonate; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; water; dimethyl sulfoxide; pentane; 3.1: Suzuki-Miyaura coupling / 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 680189-48-4
ethyl 8-(benzyloxy)-1-(3-(benzyloxy)-4-methoxyphenyl)-2-(2,4-bis(benzyloxy)-5-methoxyphenyl)-9-methoxy-5,6-dihydropyrrolo-[2,1-a]isoquinoline-3-carboxylate

: 149378-57-4
3,11-dihydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,12-dimethoxy-8,9-dihydro-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo-[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate

2: NaH / tetrahydrofuran

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1002/anie.200352043