(2-methylphenyl)phosphinic acid

Base Information

• Chemical Name: (2-methylphenyl)phosphinic acid
• CAS No.: 137622-07-2
• Molecular Formula: C₇H₉O₂P
• Molecular Weight: 156.121
• Mol file: 137622-07-2.mol

Synonyms:

Chemical Property of (2-methylphenyl)phosphinic acid

Chemical Property:

• Vapor Pressure: 0.000454mmHg at 25°C
• Boiling Point: 301.9°C at 760 mmHg
• Flash Point: 136.4°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-methylphenyl)phosphinic acid

There total 4 articles about (2-methylphenyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ortho-methylphenyl iodide (615-37-2) → 2-methyl-phenylphosphinic acid (137622-07-2)

Guidance literature:

With anilinium hypophosphorous salt; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; for 2h; Heating;

DOI:10.1021/ja005721c

Reference yield: 87.0%

2-methylphenyl bromide (95-46-5) → 2-methyl-phenylphosphinic acid (137622-07-2)

Guidance literature:

2-methylphenyl bromide; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; anilinium hypophosphite; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 120 ℃; Microwave irradiation; Inert atmosphere;

With sodium hydroxide; In diethyl ether; water;

With hydrogenchloride; In water;

DOI:10.1016/j.tet.2009.10.028

Reference yield:

(2-(methyl)phenyl)dichlorophosphine (5510-87-2) → 2-methyl-phenylphosphinic acid (137622-07-2)

Guidance literature:

With water;

upstream raw materials:

(2-(methyl)phenyl)dichlorophosphine

ortho-methylphenyl iodide

bis(2-tolyl) mercury

2-methylphenyl bromide

Downstream raw materials:

2-carboxyphenylphosphonic acid

(2-methylphenyl)phosphonic acid

(2-methyl-5-nitro-phenyl)-phosphonic acid

Refernces

• 1、 Montchamp,Dumond. "Synthesis of monosubstituted phosphinic acids: Palladium-catalyzed cross-coupling reactions of anilinium hypophosphite [8]". . p. 510 - 511. Retrieved 2007/10/03.