(2-methylphenyl)phosphonous dichloride

Base Information

• Chemical Name: (2-methylphenyl)phosphonous dichloride
• CAS No.: 5510-87-2
• Molecular Formula: C7H7Cl2P
• Molecular Weight: 193.012
• Mol file: 5510-87-2.mol

Synonyms:(2-Methylphenyl)phosphonous dichloride; phosphonous dichloride, P-(2-methylphenyl)-; LogP

Chemical Property of (2-methylphenyl)phosphonous dichloride

Chemical Property:

• Vapor Pressure: 0.0714mmHg at 25°C
• Boiling Point: 236.8 °C at 760 mmHg
• Flash Point: 97 °C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-methylphenyl)phosphonous dichloride

There total 11 articles about (2-methylphenyl)phosphonous dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

bis(diethylamino)chlorophosphine (685-83-6) + o-tolyl magnesium chloride (33872-80-9) → (2-(methyl)phenyl)dichlorophosphine (5510-87-2)

Guidance literature:

bis(diethylamino)chlorophosphine; o-tolyl magnesium chloride; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;

With hydrogenchloride; In diethyl ether; at 20 ℃;

Reference yield: 55.0%

ortho-tolylmagnesium bromide (932-31-0) → (2-(methyl)phenyl)dichlorophosphine (5510-87-2)

Guidance literature:

With bis(diethylamino)chlorophosphine; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 1h;

DOI:10.1021/acs.joc.9b03342

Reference yield: 50.0%

2-methylphenyl bromide (95-46-5) → (2-(methyl)phenyl)dichlorophosphine (5510-87-2)

Guidance literature:

2-methylphenyl bromide; With magnesium; In diethyl ether;

With bis(diethylamino)chlorophosphine; In diethyl ether; at -78 - 20 ℃; for 1h;

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 1h;

DOI:10.1002/anie.201703109

upstream raw materials:

bis(2-tolyl) mercury

N,N,N',N'-tetraethyl-P-(2-methylphenyl)phosphonous diamide

2-methylphenyl bromide

o-tolyl-phosphonic acid-dichloride

Downstream raw materials:

bis[(trifluoromethyl)phenyl](methylphenyl)phosphine

(3,5-dimethylphenyl)-(ortho-tolyl)-methyl phosphine

Refernces

• 1、 Duan, Haodong,Gao, Jun,Guo, Ge,Han, Yuxi,Leng, Kangwei,Li, Xinjin,Wang, Zhongwei,Xu, Xiaolei,Yu, Qing. "AlCl3-catalyzed C-H p hosphination of benzene: A mechanistic study". . . Retrieved 2021/01/06.
• 2、 Solomon, Sophia A.,Allen, Lucy K.,Dane, Sarah B. J.,Wright, Dominic S.. "Base-Induced 1,3-Sigmatropic rearrangement of mesitylphosphonium salts". supporting information. p. 1615 - 1619. Retrieved 2014/04/17.