Dihydroclusin

Base Information

• Chemical Name: Dihydroclusin
• CAS No.: 73149-51-6
• Molecular Formula: C22H28O7
• Molecular Weight: 404.4535
• Wikidata: Q104399138
• Mol file: 73149-51-6.mol

Synonyms:Dihydroclusin;PODOPHYLLOTOXIN, SECODEOXY SECOLACTONEDIOL;CHEBI:175230;2-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]butane-1,4-diol;9,9'-Dihydroxy-3,4,5-trimethoxy-3',4'-methylenedioxylignan

Chemical Property of Dihydroclusin

Chemical Property:

• Vapor Pressure: 3.03E-15mmHg at 25°C
• Boiling Point: 600°C at 760 mmHg
• Flash Point: 316.7°C
• Density: 1.233g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 404.18350323
• Heavy Atom Count: 29
• Complexity: 462

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)CC(CO)C(CC2=CC3=C(C=C2)OCO3)CO

Technology Process of Dihydroclusin

There total 24 articles about Dihydroclusin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(-)-isoyatein (101751-72-8) → (-)-Dihydroclusin (73149-51-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Ambient temperature;

Reference yield: 84.0%

yatein (40456-50-6,17301-91-6,61091-56-3,72690-16-5,96745-44-7,119066-80-7,128049-89-8,139560-31-9) → (-)-Dihydroclusin (73149-51-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1248/cpb.33.4333

Reference yield: 62.0%

(-)-(3S,4R,5R)-3-(3',4'5'-trimethoxybenzyl)-4-(3'',4''-methylenedioxybenzyl)-5-(1-menthyloxy)butyrolactone (140138-39-2) → (-)-Dihydroclusin (73149-51-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 72h;

upstream raw materials:

yatein

(3R,4R,5R)-4-Benzo[1,3]dioxol-5-ylmethyl-5-(2-isopropyl-5-methyl-cyclohexyloxy)-3-(3,4,5-trimethoxy-benzyl)-dihydro-furan-2-one

(E)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzylidene)dihydrofuran-2(3H)-one

(-)-isoyatein

Downstream raw materials:

(-)-(3R,4R)-3-(3,4-methylenedioxybenzyl)-4-(3,4,5-trimethoxybenzyl)tetrahydrofuran