(-)-Nomifensine

Base Information

Chemical Name:(-)-Nomifensine
CAS No.:89664-18-6
Molecular Formula:C16H18N2
Molecular Weight:238.3275
Hs Code.:
UNII:KLC3B8H9LE
DSSTox Substance ID:DTXSID801316995
Nikkaji Number:J293.622D
Wikidata:Q27225694
Pharos Ligand ID:YWQ546A24A28
Metabolomics Workbench ID:66913
ChEMBL ID:CHEMBL51697

Synonyms:(-)-Nomifensine;(-)-Nomiphensine;(S)-Nomifensine;nomifensine (S);Nomifensine, (S)-;CHEBI:180847;KLC3B8H9LE;BRN 6064060;CHEMBL51697;89664-18-6;(S)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;(S)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinoline;(4S)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;(S)-1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine;8-ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-, (S)-;UNII-KLC3B8H9LE;Lopac-N-1530;Epitope ID:116874;2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine);DTXSID801316995;BDBM50021218;NCGC00015727-01;NCGC00015727-02;NCGC00015727-05;NCGC00016811-01;LS-86010;EN300-18530957;Q27225694;(4S)-8-Amino-1,2,3,4-tetrahydro-2-methyl-4beta-phenylisoquinoline;(4S)-1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-8-ISOQUINOLINAMINE;8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (4S)-;8-ISOQUINOLINAMINE, 1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-, (S)-

Suppliers and Price of (-)-Nomifensine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-Nomifensine

Chemical Property:

Vapor Pressure:6.28E-06mmHg at 25°C
Boiling Point:378.4°C at 760 mmHg
Flash Point:164°C
PSA：29.26000
Density:1.114g/cm³
LogP:3.36520
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:238.146998583
Heavy Atom Count:18
Complexity:272

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3
Isomeric SMILES:CN1C[C@H](C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3

Technology Process of (-)-Nomifensine

There total 7 articles about (-)-Nomifensine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24526-64-5
nomifensine

: 89664-20-0
(R)-(-)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

: 89664-18-6
(S)-(+)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

Guidance literature:: With Chiracel AD column; In hexane; isopropyl alcohol; Resolution of racemate;
DOI:10.1016/j.bmcl.2012.09.050

Reference yield:

: 119810-30-9
2-[(2-Amino-benzyl)-methyl-amino]-1-phenyl-ethanone

: 89664-20-0
(R)-(-)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

: 89664-18-6
(S)-(+)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 1.5 h / 0 - 20 °C

2: sulfuric acid / dichloromethane / 0.33 h / 0 - 20 °C

3: Chiracel? AD column / hexane; isopropyl alcohol / Resolution of racemate

With sodium tetrahydroborate; sulfuric acid; In ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.09.050

Reference yield:

: 65514-97-8
N-(2-Aminobenzyl)-2-(methylamino)-1-phenyl-1-ethanol

: 89664-20-0
(R)-(-)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

: 89664-18-6
(S)-(+)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / dichloromethane / 0.33 h / 0 - 20 °C

2: Chiracel? AD column / hexane; isopropyl alcohol / Resolution of racemate

With sulfuric acid; In hexane; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.09.050