4α-Methyl-5α-cholestan-3-one

Base Information

• Chemical Name: 4α-Methyl-5α-cholestan-3-one
• CAS No.: 984-87-2
• Molecular Formula: C₂₈H₄₈O
• Molecular Weight: 400.689
• Mol file: 984-87-2.mol

Synonyms:4α-Methyl-cholestan-3-on;lophanone;4α-Methyl-5α-cholestanon-(3);4α-Methyl-5α-cholestan-3-on;(4S,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-4,10,13-trimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one;

Chemical Property of 4α-Methyl-5α-cholestan-3-one

Chemical Property:

• PSA: 17.07000
• LogP: 7.92280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4α-Methyl-5α-cholestan-3-one

There total 26 articles about 4α-Methyl-5α-cholestan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

Cholest-4-en-3-one (601-57-0) + methyl iodide (74-88-4) → 4α-methyl-5α-cholestan-3-one (984-87-2)

Guidance literature:

Cholest-4-en-3-one; With ammonia; lithium; In tetrahydrofuran; at -35 ℃; for 4h;

methyl iodide; In tetrahydrofuran; at -78 ℃;

DOI:10.1002/ejoc.200600394

Reference yield:

4β-methyl-5α-cholestan-3-one (861-13-2) → 4α-methyl-5α-cholestan-3-one (984-87-2)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1021/ja01024a032

Reference yield:

4β-Methylcholestan-3α-ol (130609-13-1) → 4α-methyl-5α-cholestan-3-one (984-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. CrO₃ / acetic acid

2: NaOMe / methanol

With chromium(VI) oxide; sodium methylate; In methanol; acetic acid;

DOI:10.1021/ja01024a032

upstream raw materials:

4-methylcholest-4-en-3-one

(3β,4α,5α)-4-methylcholestan-3-ol

4α-methyl-2,2-propanediyldimercapto-5α-cholestan-3-one

4β-methyl-5α-cholestan-3-one

Downstream raw materials:

4α-methyl-5α-cholest-1-en-3-one-(2,4-dinitro-phenylhydrazone)

(3β,4α,5α)-4-methylcholestan-3-ol

4α-methyl-5α-cholestane

Refernces

• 1、 Schaeffer, Philippe,Fache-Dany, Fabienne,Trifilieff, Sylvie,Trendel Jean M.,Albrecht, Pierre. "Characterisation of Novel 3-Carboxyalkyl-steranes Occurring in Geological Samples". . p. 12633 - 12642. Retrieved 2007/10/02.