3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione

Base Information

• Chemical Name: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione
• CAS No.: 81087-59-4
• Molecular Formula: C19H17ClN2O4
• Molecular Weight: 372.808
• Mol file: 81087-59-4.mol

Synonyms:3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione;3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione;

Chemical Property of 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione

Chemical Property:

• PSA: 81.16000
• Density: 1.334g/cm³
• LogP: 3.12590

Purity/Quality:

Safty Information:

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Technology Process of 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione

There total 3 articles about 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-chlorophenyl isocyanate (3320-83-0) → 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione (81087-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1248/cpb.39.1753

Reference yield:

2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid (67467-27-0) → 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione (81087-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1248/cpb.39.1753

Reference yield:

4-[3-(2-Chloro-phenyl)-ureido]-2,6-dimethyl-isophthalic acid 1-ethyl ester → 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione (81087-59-4) + 2-(2-Chloro-phenylamino)-5,7-dimethyl-4-oxo-4H-benzo[d][1,3]oxazine-6-carboxylic acid ethyl ester (136743-76-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 2h; Yield given. Yields of byproduct given; Heating;

DOI:10.1248/cpb.39.1753

upstream raw materials:

o-chlorophenyl isocyanate

2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid

Downstream raw materials:

3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-(2-pyrrolidin-1-yl-ethyl)-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester

3-(2-Chloro-phenyl)-5,7-dimethyl-1-(2-morpholin-4-yl-ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride

3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-pyridin-2-ylmethyl-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester

3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-[3-(N-benzyl-N-methylamino)propyl]-2,4(1H, 3H)-quinazolinedione

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