Stearoyl chloride

Base Information

• Chemical Name: Stearoyl chloride
• CAS No.: 112-76-5
• Molecular Formula: C18H35ClO
• Molecular Weight: 302.928
• Hs Code.: 29159000
• European Community (EC) Number: 204-004-5
• UNII: MYP8E32GM2
• DSSTox Substance ID: DTXSID9051583
• Nikkaji Number: J110.175G
• Wikidata: Q27284300
• Mol file: 112-76-5.mol

Synonyms:stearoyl chloride

Chemical Property of Stearoyl chloride

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Vapor Pressure: 0.000106mmHg at 25°C
• Melting Point: 21-22 °C(lit.)
• Refractive Index: 1.4540
• Boiling Point: 347.8 °C at 760 mmHg
• Flash Point: 169.8 °C
• PSA: 17.07000
• Density: 0.906 g/cm³
• LogP: 7.01330
• Storage Temp.: −20°C
• Solubility.: soluble in Toluene,Acetone
• Water Solubility.: hydrolysis
• XLogP3: 8.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 16
• Exact Mass: 302.2376434
• Heavy Atom Count: 20
• Complexity: 204

Purity/Quality:

98% or more ^*data from raw suppliers

Stearoyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 14-34
• Safety Statements: 26-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Stearates
• Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)Cl
• Uses: Stearoyl Chloride is usually used in the synthesis of tumor-associated macrophages and antitumor agents. Stearoyl chloride was used in the synthesis of 4-fluoroceramide. It was also used in the preparation of shimofuridin analogs: 2′-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine.

Technology Process of Stearoyl chloride

There total 7 articles about Stearoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

stearic acid (57-11-4) → Stearoyl chloride (112-76-5)

Guidance literature:

With thionyl chloride; In toluene; at 20 ℃; Reflux;

Reference yield: 95.7%

→ Stearoyl chloride (112-76-5)

Guidance literature:

Reference yield: 60.1%

→ 1-(α-Cyclopropylcarbonyl-2-fluorobenzyl)-4-stearoylthiopiperidine (204204-87-5) + Stearoyl chloride (112-76-5)

Guidance literature:

upstream raw materials:

phosgene

stearic acid

oxalyl dichloride

Stearinsaeure-isopropenyl-ester

Downstream raw materials:

1-(piperidin-1-yl)octadecan-1-one

1-[2]furyl-octadecan-1-one

1-[2]thienyl-octadecan-1-one

retinyl stearate

Refernces

Synthesis of structurally weil-defined triglyceryl di-, tri-, and tetra-fatty acid esters as new oil gelators

10.1055/s-0028-1083601

The research focuses on the development and synthesis of chemically modified linear and cyclic polyglycerols and their esters, specifically triglyceryl di-, tri-, and tetra-fatty acid esters, which are structurally well-defined and have a single polymerization degree. The purpose of this study is to create new oil gelators capable of gelling up cooking oils, with a particular emphasis on understanding the role of alkyl chain length in the gelation process. The study concluded that these triglyceryl ester gelators exhibit prominent gelation ability and can gel a wide variety of oils. Key chemicals used in the synthesis process include triglycerol, fatty acid esters such as stearic, myristic, palmitic, and arachidic acids, benzyl bromide, stearoyl chloride, and various reagents for protection and deprotection steps, as well as catalysts and solvents like pyridine, 4-(dimethylamino)pyridine, and palladium on carbon for hydrogenolysis.