1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-

Base Information

Chemical Name:1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-
CAS No.:199594-82-6
Molecular Formula:C₁₅H₁₂F₂N₂
Molecular Weight:258.27
Hs Code.:
DSSTox Substance ID:DTXSID80173741
Nikkaji Number:J925.398J
Wikidata:Q83043766
ChEMBL ID:CHEMBL134470
Mol file:199594-82-6.mol

Synonyms:199594-82-6;1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-;1-((2,6-Difluorophenyl)methyl)-4-methylbenzimidazole;1-[(2,6-difluorophenyl)methyl]-4-methylbenzimidazole;1-(2,6-difluorobenzyl)-4-methylbenzimidazole;1-(2,6-difluorobenzyl)-4-methyl-1h-benzimidazole;1H-Benzimidazole, 1-[(2,6-difluorophenyl)methyl]-4-methyl-;CHEMBL134470;SCHEMBL5205094;DTXSID80173741;1-[(2,6-difluorophenyl)methyl]-4-methyl-benzimidazole

Suppliers and Price of 1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-

Chemical Property:

Vapor Pressure:1.54E-06mmHg at 25°C
Boiling Point:397.8°C at 760 mmHg
PKA:4.48±0.10(Predicted)
Flash Point:194.4°C
PSA：17.82000
Density:1.23g/cm³
LogP:3.67120
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:258.09685472
Heavy Atom Count:19
Complexity:303

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=CC=C1)N(C=N2)CC3=C(C=CC=C3F)F

Technology Process of 1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-

There total 6 articles about 1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 199594-81-5
1-(2,6-difluorobenzyl)-2-hydroxymethyl-4-methylbenzoimidazole

: 199594-82-6
1-(2,6-difluorobenzyl)-4-methylbenzoimidazole

Guidance literature:: With potassium permanganate; sulfuric acid; for 1h; Ambient temperature;
DOI:10.1021/jm970096g

Reference yield: 15.0%

: 199594-81-5
1-(2,6-difluorobenzyl)-2-hydroxymethyl-4-methylbenzoimidazole

: 199594-82-6
1-(2,6-difluorobenzyl)-4-methylbenzoimidazole

: 1-(2,6-difluorobenzyl)-2-formyl-4-methylbenzimidazole

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h;
DOI:10.1021/jm970096g

Reference yield:

: 191794-20-4
2-hydroxymethyl-4-methylbenzimidazole

: 199594-82-6
1-(2,6-difluorobenzyl)-4-methylbenzoimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / pyridine / 4 h / Ambient temperature

2: 93 percent / NaH / tetrahydrofuran / 4 h

3: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

4: 80 percent / 1.5 M aq. H₂SO₄, KMnO₄ / 1 h / Ambient temperature

With pyridine; potassium permanganate; sulfuric acid; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm970096g