1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole
CAS No.:199594-63-3
Molecular Formula:C₂₂H₂₈F₂N₂OSi
Molecular Weight:402.559
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

Chemical Property:

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Technology Process of 1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

There total 3 articles about 1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 85118-00-9
2,6-Difluorobenzyl bromide

: 199594-46-2
2-(t-Butyldimethylsilyloxymethyl)-4-methylbenzimidazole

: 199594-63-3
1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 4h;
DOI:10.1021/jm970096g

Reference yield:

: 191794-20-4
2-hydroxymethyl-4-methylbenzimidazole

: 199594-63-3
1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / pyridine / 4 h / Ambient temperature

2: 93 percent / NaH / tetrahydrofuran / 4 h

With pyridine; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm970096g

Reference yield:

: 2687-25-4
3-methyl-1,2-benzenediamine

: 199594-63-3
1-(2,6-difluorobenzyl)-2-t-butyldimethylsiloxymethyl-4-methylbenzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / aq. HCl / 2 h / Heating

2: 84 percent / pyridine / 4 h / Ambient temperature

3: 93 percent / NaH / tetrahydrofuran / 4 h

With pyridine; hydrogenchloride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm970096g