Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

Base Information

Chemical Name:Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester
CAS No.:82585-95-3
Molecular Formula:C16H16FN5O2
Molecular Weight:329.334
Hs Code.:
NSC Number:346889
DSSTox Substance ID:DTXSID20231894
Wikidata:Q83112888
ChEMBL ID:CHEMBL274897

Synonyms:82585-95-3;Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester;Ethyl (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate;ETHYL (5-AMINO-3-(4-FLUOROPHENYL)-1,2-DIHYDROPYRIDO[3,4-B]PYRAZIN-7-YL)CARBAMATE;NSC346889;ethyl N-[5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate;CHEMBL274897;SCHEMBL11009886;DTXSID20231894;NSC 346889;NSC-346889;Carbamic acid,5-amino-3-[4'-fluorophenyl]-1,2- dihydropyrido[3,4-b]pyrazin-7-yl,ethyl ester

Suppliers and Price of Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 5 raw suppliers

Chemical Property of Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

Chemical Property:

Vapor Pressure:3.2E-09mmHg at 25°C
Boiling Point:475.9°C at 760 mmHg
Flash Point:241.6°C
Density:1.45g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:329.12880293
Heavy Atom Count:24
Complexity:481

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)NC1=NC(=C2C(=C1)NCC(=N2)C3=CC=C(C=C3)F)N

Technology Process of Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester

There total 4 articles about Carbamic acid, (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 82585-77-1
{6-Amino-4-[2-(4-fluoro-phenyl)-2-oxo-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester

: 82585-95-3
ethyl 5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate

Guidance literature:: With hydrogen; nickel; In 1,4-dioxane; ethanol; for 12h; under 760 Torr; Heating;
DOI:10.1021/jm00351a008

Reference yield:

: 82585-34-0
2-Amino-1-(4-fluoro-phenyl)-ethanone oxime

: 82585-95-3
ethyl 5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Et₃N / ethanol / 2 h / 75 °C

2: 48 percent / 1N aq. HCl / dioxane / 24 h / 60 °C

3: 78 percent / H₂ / Raney nickel / ethanol; dioxane / 12 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008

Reference yield:

: 82585-63-5
(6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

: 82585-95-3
ethyl 5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / 1N aq. HCl / dioxane / 24 h / 60 °C

2: 78 percent / H₂ / Raney nickel / ethanol; dioxane / 12 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; nickel; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00351a008