(6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

Base Information

• Chemical Name: (6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester
• CAS No.: 82585-63-5
• Molecular Formula: C₁₆H₁₇FN₆O₅
• Molecular Weight: 392.347
• Mol file: 82585-63-5.mol

Synonyms:(6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

Chemical Property of (6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester

There total 1 articles about (6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) + 2-Amino-1-(4-fluoro-phenyl)-ethanone oxime (82585-34-0) → (6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester (82585-63-5)

Guidance literature:

With triethylamine; In ethanol; at 75 ℃; for 2h;

DOI:10.1021/jm00351a008

Reference yield: 48.0%

(6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester (82585-63-5) → {6-Amino-4-[2-(4-fluoro-phenyl)-2-oxo-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester (82585-77-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 24h;

DOI:10.1021/jm00351a008

Reference yield:

(6-Amino-4-{2-(4-fluoro-phenyl)-2-[(Z)-hydroxyimino]-ethylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester (82585-63-5) → ethyl 5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate (82585-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / 1N aq. HCl / dioxane / 24 h / 60 °C

2: 78 percent / H₂ / Raney nickel / ethanol; dioxane / 12 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; nickel; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00351a008

upstream raw materials:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

2-Amino-1-(4-fluoro-phenyl)-ethanone oxime

Downstream raw materials:

{6-Amino-4-[2-(4-fluoro-phenyl)-2-oxo-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester

ethyl 5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate