4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid

Base Information

• Chemical Name: 4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid
• CAS No.: 141901-74-8
• Molecular Formula: C₂₂H₁₇F₃O₃
• Molecular Weight: 386.37
• Mol file: 141901-74-8.mol

Synonyms:4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid

Chemical Property of 4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid

Chemical Property:

• Vapor Pressure: 3.64E-11mmHg at 25°C
• Boiling Point: 508.6°Cat760mmHg
• Flash Point: 261.4°C
• PSA: 57.53000
• Density: 1.323g/cm³
• LogP: 4.73540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid

There total 6 articles about 4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + (4-biphenylyl)acetic acid (5728-52-9) → 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8) + 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -5 - 0 ℃; for 0.5h;

Reference yield: 55.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + (4-biphenylyl)acetic acid (5728-52-9) → 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8) + 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -5 - 0 ℃; for 0.5h;

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + (4-biphenylyl)acetic acid (5728-52-9) → 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8) + 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8) + 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8) + 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid (141857-33-2,141857-35-4,141901-71-5,141901-72-6,141901-73-7,141901-74-8)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -5 - 0 ℃; for 0.5h; Yield given;

upstream raw materials:

4-Trifluoromethylbenzaldehyde

(4-biphenylyl)acetic acid

Downstream raw materials:

2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid methyl ester

2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid methyl ester