1-Naphthylhydrazine hydrochloride

Base Information

• Chemical Name: 1-Naphthylhydrazine hydrochloride
• CAS No.: 2243-56-3
• Molecular Formula: C10H10N2^.HCl
• Molecular Weight: 194.664
• Hs Code.: 2928000090
• European Community (EC) Number: 675-793-5
• NSC Number: 5527,4158
• DSSTox Substance ID: DTXSID60883816
• Mol file: 2243-56-3.mol

Synonyms:1-Naphthylhydrazine hydrochloride;2243-56-3;naphthalen-1-ylhydrazine hydrochloride;1-Naphthylhydrazine HCl;1-Naphthylhydrazine, HCl;1-Hydrazinonaphthalene monohydrochloride;Hydrazine, 1-naphthalenyl-, monohydrochloride;naphthalen-1-ylhydrazine;hydrochloride;(naphthalen-1-yl)hydrazine hydrochloride;MFCD00060157;Hydrazine, 1-naphthalenyl-, hydrochloride (1:1);.alpha.-Naphthylhydrazine monohydrochloride;NSC 4158;NSC 5527;alpha-Naphthylhydrazine monohydrochloride;C10H10N2.ClH;naphthylhydrazine hydrochloride;SCHEMBL526877;DTXSID60883816;NSC4158;NSC5527;1-naphthyl hydrazine hydrochloride;NSC-4158;NSC-5527;1-(1-naphthyl)hydrazine hydrochloride;AKOS009149190;CS-W010636;GS-3162;SY025959;FT-0634161;N0064;EN300-60074;1-Naphthalenyl hydrazine hydrochloride, AldrichCPR;A816202;J-510149

Chemical Property of 1-Naphthylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.87E-05mmHg at 25°C
• Melting Point: 245-250°C(lit.)
• Boiling Point: 362.9 °C at 760 mmHg
• Flash Point: 203.9 °C
• PSA: 38.05000
• Density: 1.215g/cm3
• LogP: 3.70070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 194.0610761
• Heavy Atom Count: 13
• Complexity: 147

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Naphthalenyl hydrazine hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 20/21/22-36/37/38:
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-51-22
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2NN.Cl

Technology Process of 1-Naphthylhydrazine hydrochloride

There total 2 articles about 1-Naphthylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

naphthalen-2-ylamine (91-59-8) → 1-naphthylhydrazine hydrochloride (2243-56-3)

Guidance literature:

naphthalen-2-ylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With tin(ll) chloride; In water; at 0 ℃; for 3.5h;

Reference yield:

1-amino-naphthalene (134-32-7) → 1-naphthylhydrazine hydrochloride (2243-56-3)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; sodium nitrite; Multistep reaction; 1.) -5 deg C to 0 deg C, 0.75 h, 2.) 1 h;

DOI:10.1021/jm00168a028

Reference yield: 95.0%

3-methyl-butan-2-one (563-80-4) + 1-naphthylhydrazine hydrochloride (2243-56-3) → 2,3,3-trimethylbenzo[e]indole (41532-84-7)

Guidance literature:

With acetic acid; at 20 ℃; for 6.5h; Reflux;

DOI:10.1007/s11172-016-1642-2

upstream raw materials:

1-amino-naphthalene

naphthalen-2-ylamine

Downstream raw materials:

3-methyl-2-phenyl-1H-benzo[g]indole

6,13-dihydro-5H-dibenzo[a,i]carbazole

2,2,2-trifluoroacetophenone 1-naphthylhydrazone

8-methyl-11H-benzo[a]carbazole

Refernces

• 1、 Portoghese,Sultana,Takemori. "Design of peptidomimetic δ opioid receptor antagonists using the message-address concept". . p. 1714 - 1720. Retrieved 2007/10/02.