Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide

Base Information

Chemical Name:Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide
CAS No.:84044-29-1
Molecular Formula:C25H23ClN4O5
Molecular Weight:494.934
Hs Code.:
DSSTox Substance ID:DTXSID301004339

Synonyms:BRN 5183965;84044-29-1;Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide;C25H23ClN4O5;DTXSID301004339;C25-H23-Cl-N4-O5;LS-38432;N-(7-Chloro-2-hydroxy-5-phenyl-3H-1,4-benzodiazepin-3-yl)-3,4,5-trimethoxybenzene-1-carbohydrazonic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:494.1356975
Heavy Atom Count:35
Complexity:763

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C(=O)NNC2C(=O)NC3=C(C=C(C=C3)Cl)C(=N2)C4=CC=CC=C4

Technology Process of Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide

There total 2 articles about Benzoic acid, 3,4,5-trimethoxy-, 2-(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 75878-00-1
7-Chloro-5-phenyl-3-hydrazino-2,3-dihydro-1H-1,4-benzodiazepin-2-one

: 84044-29-1
7-Chloro-5-phenyl-3-(3',4',5'-trimethoxybenzoylhydrazino)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:: With pyridine; at 30 - 35 ℃; for 1h;
DOI:10.1007/BF00773096

Reference yield:

: 5358-44-1
3,7-dichloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one

: 84044-29-1
7-Chloro-5-phenyl-3-(3',4',5'-trimethoxybenzoylhydrazino)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 78.5 percent / 85percent hydrazine hydrate / 0.5 h / 10 - 12 °C

2: 89.5 percent / pyridine / 1 h / 30 - 35 °C

With pyridine; hydrazine hydrate;
DOI:10.1007/BF00773096